Gene name: OPHN1

Uniprot entry:

O60890

Protein names:

Oligophrenin-1

Protein sequence:

1_MGHPP 6_ LEFSD 11_ CYLDS 16_ PDFRE 21_ RLKCY 26_ EQELE 31_ RTNKF 36_ IKDVI 41_ KDGNA 46_ LISAM 51_ RNYSS 56_ AVQKF 61_ SQTLQ 66_ SFQFD 71_ FIGDT 76_ LTDDE 81_ INIAE 86_ SFKEF 91_ AELLN 96_ EVENE 101_ RMMMV 106_ HNASD 111_ LLIKP 116_ LENFR 121_ KEQIG 126_ FTKER 131_ KKKFE 136_ KDGER 141_ FYSLL 146_ DRHLH 151_ LSSKK 156_ KESQL 161_ QEADL 166_ QVDKE 171_ RHNFF 176_ ESSLD 181_ YVYQI 186_ QEVQE 191_ SKKFN 196_ IVEPV 201_ LAFLH 206_ SLFIS 211_ NSLTV 216_ ELTQD 221_ FLPYK 226_ QQLQL 231_ SLQNT 236_ RNHFS 241_ STREE 246_ MEELK 251_ KRMKE 256_ APQTC 261_ KLPGQ 266_ PTIEG 271_ YLYTQ 276_ EKWAL 281_ GISWV 286_ KYYCQ 291_ YEKET 296_ KTLTM 301_ TPMEQ 306_ KPGAK 311_ QGPLD 316_ LTLKY 321_ CVRRK 326_ TESID 331_ KRFCF 336_ DIETN 341_ ERPGT 346_ ITLQA 351_ LSEAN 356_ RRLWM 361_ EAMDG 366_ KEPIY 371_ HSPIT 376_ KQQEM 381_ ELNEV 386_ GFKFV 391_ RKCIN 396_ IIETK 401_ GIKTE 406_ GLYRT 411_ VGSNI 416_ QVQKL 421_ LNAFF 426_ DPKCP 431_ GDVDF 436_ HNSDW 441_ DIKTI 446_ TSSLK 451_ FYLRN 456_ LSEPV 461_ MTYRL 466_ HKELV 471_ SAAKS 476_ DNLDY 481_ RLGAI 486_ HSLVY 491_ KLPEK 496_ NREML 501_ ELLIR 506_ HLVNV 511_ CEHSK 516_ ENLMT 521_ PSNMG 526_ VIFGP 531_ TLMRA 536_ QEDTV 541_ AAMMN 546_ IKFQN 551_ IVVEI 556_ LIEHF 561_ GKIYL 566_ GPPEE 571_ SAAPP 576_ VPPPR 581_ VTARR 586_ HKPIT 591_ ISKRL 596_ LRERT 601_ VFYTS 606_ SLDES 611_ EDEIQ 616_ HQTPN 621_ GTITS 626_ SIEPP 631_ KPPQH 636_ PKLPI 641_ QRSGE 646_ TDPGR 651_ KSPSR 656_ PILDG 661_ KLEPC 666_ PEVDV 671_ GKLVS 676_ RLQDG 681_ GTKIT 686_ PKATN 691_ GPMPG 696_ SGPTK 701_ TPSFH 706_ IKRPA 711_ PRPLA 716_ HHKEG 721_ DADSF 726_ SKVRP 731_ PGEKP 736_ TIIRP 741_ PVRPP 746_ DPPCR 751_ AATPQ 756_ KPEPK 761_ PDIVA 766_ GNAGE 771_ ITSSV 776_ VASRT 781_ RFFET 786_ ASRKT 791_ GSSQG 796_RLPGD

Protein annotations

Protein functions:

1: Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation (By similarity)