Receptor activity-modifying protein 1 (Calcitonin-receptor-like receptor activity-modifying protein 1) (CRLR activity-modifying protein 1)
1_MARAL 6_ CRLPR 11_ RGLWL 16_ LLAHH 21_ LFMTT 26_ ACQEA 31_ NYGAL 36_ LRELC 41_ LTQFQ 46_ VDMEA 51_ VGETL 56_ WCDWG 61_ RTIRS 66_ YRELA 71_ DCTWH 76_ MAEKL 81_ GCFWP 86_ NAEVD 91_ RFFLA 96_ VHGRY 101_ FRSCP 106_ ISGRA 111_ VRDPP 116_ GSILY 121_ PFIVV 126_ PITVT 131_ LLVTA 136_ LVVWQ 141_SKRTE
1: Accessory protein that interacts with and modulates the function of G-protein coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL) and calcitonin receptor (CALCR) (PubMed:33602864, PubMed:9620797, PubMed:35324283, PubMed:38603770). Required for the transport of CALCRL to the plasma membrane (PubMed:9620797). Together with CALCRL, form the receptor complex for the calcitonin gene-related peptides CGRP1/CALCA and CGRP2/CALCB (PubMed:33602864, PubMed:9620797). Together with CALCR, form the AMYR1 receptor complex for amylin/IAPP and CGRP1/CALCA (PubMed:35324283, PubMed:38603770)