Receptor activity-modifying protein 2 (Calcitonin-receptor-like receptor activity-modifying protein 2) (CRLR activity-modifying protein 2)
1_MASLR 6_ VERAG 11_ GPRLP 16_ RTRVG 21_ RPAAL 26_ RLLLL 31_ LGAVL 36_ NPHEA 41_ LAQPL 46_ PTTGT 51_ PGSEG 56_ GTVKN 61_ YETAV 66_ QFCWN 71_ HYKDQ 76_ MDPIE 81_ KDWCD 86_ WAMIS 91_ RPYST 96_ LRDCL 101_ EHFAE 106_ LFDLG 111_ FPNPL 116_ AERII 121_ FETHQ 126_ IHFAN 131_ CSLVQ 136_ PTFSD 141_ PPEDV 146_ LLAMI 151_ IAPIC 156_ LIPFL 161_ ITLVV 166_WRSKD
1: Accessory protein that interacts with and modulates the function of G-protein coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL) and calcitonin receptor (CALCR) (PubMed:9620797). Required for the transport of CALCRL to the plasma membrane (PubMed:9620797). Together with CALCRL, form a receptor complex for adrenomedullin/ADM (PubMed:22102369, PubMed:32296767, PubMed:9620797). Together with CALCR, act as a receptor complex for calcitonin/CT/CALC (PubMed:35324283). Together with CALCR, also act as a receptor complex for amylin/IAPP (PubMed:35324283)