Receptor activity-modifying protein 3 (Calcitonin-receptor-like receptor activity-modifying protein 3) (CRLR activity-modifying protein 3)
1_METGA 6_ LRRPQ 11_ LLPLL 16_ LLLCG 21_ GCPRA 26_ GGCNE 31_ TGMLE 36_ RLPLC 41_ GKAFA 46_ DMMGK 51_ VDVWK 56_ WCNLS 61_ EFIVY 66_ YESFT 71_ NCTEM 76_ EANVV 81_ GCYWP 86_ NPLAQ 91_ GFITG 96_ IHRQF 101_ FSNCT 106_ VDRVH 111_ LEDPP 116_ DEVLI 121_ PLIVI 126_ PVVLT 131_ VAMAG 136_ LVVWR 141_SKRTD
1: Accessory protein that interacts with and modulates the function of G-protein coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL), calcitonin receptor (CALCR) and G-protein coupled estrogen receptor 1 (GPER1) (PubMed:23674134, PubMed:9620797). Required for the transport of CALCRL and GPER1 receptors to the plasma membrane (PubMed:23674134, PubMed:9620797). Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner (PubMed:23674134). Together with CALCRL, form a receptor complex for adrenomedullin/ADM and intermedin/ADM2 (PubMed:32296767). Together with CALCR, act as a receptor complex for amylin/IAPP (PubMed:35324283)