Sphingomyelin phosphodiesterase 2 (EC 3.1.4.12) (Lyso-platelet-activating factor-phospholipase C) (Lyso-PAF-PLC) (Neutral sphingomyelinase) (N-SMase) (nSMase) (nSMase1)
1_MKPNF 6_ SLRLR 11_ IFNLN 16_ CWGIP 21_ YLSKH 26_ RADRM 31_ RRLGD 36_ FLNQE 41_ SFDLA 46_ LLEEV 51_ WSEQD 56_ FQYLR 61_ QKLSP 66_ TYPAA 71_ HHFRS 76_ GIIGS 81_ GLCVF 86_ SKHPI 91_ QELTQ 96_ HIYTL 101_ NGYPY 106_ MIHHG 111_ DWFSG 116_ KAVGL 121_ LVLHL 126_ SGMVL 131_ NAYVT 136_ HLHAE 141_ YNRQK 146_ DIYLA 151_ HRVAQ 156_ AWELA 161_ QFIHH 166_ TSKKA 171_ DVVLL 176_ CGDLN 181_ MHPED 186_ LGCCL 191_ LKEWT 196_ GLHDA 201_ YLETR 206_ DFKGS 211_ EEGNT 216_ MVPKN 221_ CYVSQ 226_ QELKP 231_ FPFGV 236_ RIDYV 241_ LYKAV 246_ SGFYI 251_ SCKSF 256_ ETTTG 261_ FDPHR 266_ GTPLS 271_ DHEAL 276_ MATLF 281_ VRHSP 286_ PQQNP 291_ SSTHG 296_ PAERS 301_ PLMCV 306_ LKEAW 311_ TELGL 316_ GMAQA 321_ RWWAT 326_ FASYV 331_ IGLGL 336_ LLLAL 341_ LCVLA 346_ AGGGA 351_ GEAAI 356_ LLWTP 361_ SVGLV 366_ LWAGA 371_ FYLFH 376_ VQEVN 381_ GLYRA 386_ QAELQ 391_ HVLGR 396_ AREAQ 401_ DLGPE 406_ PQPAL 411_ LLGQQ 416_EGDRT
1: Catalyzes, at least in vitro, the hydrolysis of sphingomyelin to form ceramide and phosphocholine (PubMed:10608884). Also hydrolyzes 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor) in vivo (PubMed:10608884). Also acts on 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and sphingosylphosphocholine (PubMed:10608884, PubMed:14741383)