Gene name: PPP1R11

Uniprot entry:

O60927

Protein names:

E3 ubiquitin-protein ligase PPP1R11 (EC 2.3.2.27) (Hemochromatosis candidate gene V protein) (HCG V) (Protein phosphatase 1 regulatory subunit 11) (Protein phosphatase inhibitor 3)

Protein sequence:

1_MAEAG 6_ AGLSE 11_ TVTET 16_ TVTVT 21_ TEPEN 26_ RSLTI 31_ KLRKR 36_ KPEKK 41_ VEWTS 46_ DTVDN 51_ EHMGR 56_ RSSKC 61_ CCIYE 66_ KPRAF 71_ GESST 76_ ESDEE 81_ EEEGC 86_ GHTHC 91_ VRGHR 96_ KGRRR 101_ ATLGP 106_ TPTTP 111_ PQPPD 116_ PSQPP 121_PGPMQ

Protein annotations

Protein functions:

1: Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2 (PubMed:27805901). Inhibitor of protein phosphatase 1 (PubMed:9843442)