Inward rectifier potassium channel 13 (Inward rectifier K(+) channel Kir7.1) (Potassium channel, inwardly rectifying subfamily J member 13)
1_MDSSN 6_ CKVIA 11_ PLLSQ 16_ RYRRM 21_ VTKDG 26_ HSTLQ 31_ MDGAQ 36_ RGLAY 41_ LRDAW 46_ GILMD 51_ MRWRW 56_ MMLVF 61_ SASFV 66_ VHWLV 71_ FAVLW 76_ YVLAE 81_ MNGDL 86_ ELDHD 91_ APPEN 96_ HTICV 101_ KYITS 106_ FTAAF 111_ SFSLE 116_ TQLTI 121_ GYGTM 126_ FPSGD 131_ CPSAI 136_ ALLAI 141_ QMLLG 146_ LMLEA 151_ FITGA 156_ FVAKI 161_ ARPKN 166_ RAFSI 171_ RFTDT 176_ AVVAH 181_ MDGKP 186_ NLIFQ 191_ VANTR 196_ PSPLT 201_ SVRVS 206_ AVLYQ 211_ ERENG 216_ KLYQT 221_ SVDFH 226_ LDGIS 231_ SDECP 236_ FFIFP 241_ LTYYH 246_ SITPS 251_ SPLAT 256_ LLQHE 261_ NPSHF 266_ ELVVF 271_ LSAMQ 276_ EGTGE 281_ ICQRR 286_ TSYLP 291_ SEIML 296_ HHCFA 301_ SLLTR 306_ GSKGE 311_ YQIKM 316_ ENFDK 321_ TVPEF 326_ PTPLV 331_ SKSPN 336_ RTDLD 341_ IHING 346_ QSIDN 351_FQISE
1: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium