Ribonuclease H1 (RNase H1) (EC 3.1.26.4) (Ribonuclease H type II)
1_MSWLL 6_ FLAHR 11_ VALAA 16_ LPCRR 21_ GSRGF 26_ GMFYA 31_ VRRGR 36_ KTGVF 41_ LTWNE 46_ CRAQV 51_ DRFPA 56_ ARFKK 61_ FATED 66_ EAWAF 71_ VRKSA 76_ SPEVS 81_ EGHEN 86_ QHGQE 91_ SEAKA 96_ SKRLR 101_ EPLDG 106_ DGHES 111_ AEPYA 116_ KHMKP 121_ SVEPA 126_ PPVSR 131_ DTFSY 136_ MGDFV 141_ VVYTD 146_ GCCSS 151_ NGRRR 156_ PRAGI 161_ GVYWG 166_ PGHPL 171_ NVGIR 176_ LPGRQ 181_ TNQRA 186_ EIHAA 191_ CKAIE 196_ QAKTQ 201_ NINKL 206_ VLYTD 211_ SMFTI 216_ NGITN 221_ WVQGW 226_ KKNGW 231_ KTSAG 236_ KEVIN 241_ KEDFV 246_ ALERL 251_ TQGMD 256_ IQWMH 261_ VPGHS 266_ GFIGN 271_ EEADR 276_ LAREG 281_AKQSE
1: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids (PubMed:10497183). Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site and behind the elongating RNAp II (PubMed:21700224)