Cystinosin
1_MIRNW 6_ LTIFI 11_ LFPLK 16_ LVEKC 21_ ESSVS 26_ LTVPP 31_ VVKLE 36_ NGSST 41_ NVSLT 46_ LRPPL 51_ NATLV 56_ ITFEI 61_ TFRSK 66_ NITIL 71_ ELPDE 76_ VVVPP 81_ GVTNS 86_ SFQVT 91_ SQNVG 96_ QLTVY 101_ LHGNH 106_ SNQTG 111_ PRIRF 116_ LVIRS 121_ SAISI 126_ INQVI 131_ GWIYF 136_ VAWSI 141_ SFYPQ 146_ VIMNW 151_ RRKSV 156_ IGLSF 161_ DFVAL 166_ NLTGF 171_ VAYSV 176_ FNIGL 181_ LWVPY 186_ IKEQF 191_ LLKYP 196_ NGVNP 201_ VNSND 206_ VFFSL 211_ HAVVL 216_ TLIII 221_ VQCCL 226_ YERGG 231_ QRVSW 236_ PAIGF 241_ LVLAW 246_ LFAFV 251_ TMIVA 256_ AVGVT 261_ TWLQF 266_ LFCFS 271_ YIKLA 276_ VTLVK 281_ YFPQA 286_ YMNFY 291_ YKSTE 296_ GWSIG 301_ NVLLD 306_ FTGGS 311_ FSLLQ 316_ MFLQS 321_ YNNDQ 326_ WTLIF 331_ GDPTK 336_ FGLGV 341_ FSIVF 346_ DVVFF 351_ IQHFC 356_ LYRKR 361_PGYDQ
1: Cystine/H(+) symporter that mediates export of cystine, the oxidized dimer of cysteine, from lysosomes (PubMed:11689434, PubMed:15128704, PubMed:18337546, PubMed:22232659, PubMed:29467429, PubMed:33208952, PubMed:36113465). Plays an important role in melanin synthesis by catalyzing cystine export from melanosomes, possibly by inhibiting pheomelanin synthesis (PubMed:22649030). In addition to cystine export, also acts as a positive regulator of mTORC1 signaling in kidney proximal tubular cells, via interactions with components of the v-ATPase and Ragulator complexes (PubMed:36113465). Also involved in small GTPase-regulated vesicle trafficking and lysosomal localization of LAMP2A, independently of cystine transporter activity (By similarity)