Sodium channel subunit beta-2
1_MHRDA 6_ WLPRP 11_ AFSLT 16_ GLSLF 21_ FSLVP 26_ PGRSM 31_ EVTVP 36_ ATLNV 41_ LNGSD 46_ ARLPC 51_ TFNSC 56_ YTVNH 61_ KQFSL 66_ NWTYQ 71_ ECNNC 76_ SEEMF 81_ LQFRM 86_ KIINL 91_ KLERF 96_ QDRVE 101_ FSGNP 106_ SKYDV 111_ SVMLR 116_ NVQPE 121_ DEGIY 126_ NCYIM 131_ NPPDR 136_ HRGHG 141_ KIHLQ 146_ VLMEE 151_ PPERD 156_ STVAV 161_ IVGAS 166_ VGGFL 171_ AVVIL 176_ VLMVV 181_ KCVRR 186_ KKEQK 191_ LSTDD 196_ LKTEE 201_ EGKTD 206_GEGNP
1: Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes (PubMed:19808477, PubMed:23559163, PubMed:26894959, PubMed:30765605, PubMed:30765606, PubMed:35277491, PubMed:36823201). Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:19808477, PubMed:23559163, PubMed:26894959). The accessory beta subunits participate in localization and functional modulation of the Nav channels (PubMed:19808477, PubMed:23559163). Modulates the activity of SCN1A/Nav1.1, SCN2A/Nav1.2, SCN2A/Nav1.3, SCN5A/Nav1.5, SCN8A/Nav1.6, SCN9A/Nav1.7 and SCN10A/Nav1.8 (PubMed:19808477, PubMed:23559163, PubMed:26894959, PubMed:30765605, PubMed:30765606, PubMed:35277491, PubMed:36823201)