mRNA-capping enzyme (HCAP1) (HCE) [Includes: mRNA 5'-triphosphate monophosphatase (EC 3.6.1.74) (mRNA 5'-phosphatase); mRNA guanylyltransferase (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase)]
1_MAHNK 6_ IPPRW 11_ LNCPR 16_ RGQPV 21_ AGRFL 26_ PLKTM 31_ LGPRY 36_ DSQVA 41_ EENRF 46_ HPSML 51_ SNYLK 56_ SLKVK 61_ MGLLV 66_ DLTNT 71_ SRFYD 76_ RNDIE 81_ KEGIK 86_ YIKLQ 91_ CKGHG 96_ ECPTT 101_ ENTET 106_ FIRLC 111_ ERFNE 116_ RNPPE 121_ LIGVH 126_ CTHGF 131_ NRTGF 136_ LICAF 141_ LVEKM 146_ DWSIE 151_ AAVAT 156_ FAQAR 161_ PPGIY 166_ KGDYL 171_ KELFR 176_ RYGDI 181_ EEAPP 186_ PPLLP 191_ DWCFE 196_ DDEDE 201_ DEDED 206_ GKKES 211_ EPGSS 216_ ASFGK 221_ RRKER 226_ LKLGA 231_ IFLEG 236_ VTVKG 241_ VTQVT 246_ TQPKL 251_ GEVQQ 256_ KCHQF 261_ CGWEG 266_ SGFPG 271_ AQPVS 276_ MDKQN 281_ IKLLD 286_ LKPYK 291_ VSWKA 296_ DGTRY 301_ MMLID 306_ GTNEV 311_ FMIDR 316_ DNSVF 321_ HVSNL 326_ EFPFR 331_ KDLRM 336_ HLSNT 341_ LLDGE 346_ MIIDR 351_ VNGQA 356_ VPRYL 361_ IYDII 366_ KFNSQ 371_ PVGDC 376_ DFNVR 381_ LQCIE 386_ REIIS 391_ PRHEK 396_ MKTGL 401_ IDKTQ 406_ EPFSV 411_ RNKPF 416_ FDICT 421_ SRKLL 426_ EGNFA 431_ KEVSH 436_ EMDGL 441_ IFQPT 446_ GKYKP 451_ GRCDD 456_ ILKWK 461_ PPSLN 466_ SVDFR 471_ LKITR 476_ MGGEG 481_ LLPQN 486_ VGLLY 491_ VGGYE 496_ RPFAQ 501_ IKVTK 506_ ELKQY 511_ DNKII 516_ ECKFE 521_ NNSWV 526_ FMRQR 531_ TDKSF 536_ PNAYN 541_ TAMAV 546_ CNSIS 551_ NPVTK 556_ EMLFE 561_ FIDRC 566_ TAASQ 571_ GQKRK 576_ HHLDP 581_ DTELM 586_ PPPPP 591_KRPRP
1: Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate