Iron-sulfur clusters transporter ABCB7, mitochondrial (ATP-binding cassette sub-family B member 7, mitochondrial) (ATP-binding cassette transporter 7) (ABC transporter 7 protein)
1_MALLA 6_ MHSWR 11_ WAAAA 16_ AAFEK 21_ RRHSA 26_ ILIRP 31_ LVSVS 36_ GSGPQ 41_ WRPHQ 46_ LGALG 51_ TARAY 56_ QIPES 61_ LKSIT 66_ WQRLG 71_ KGNSG 76_ QFLDA 81_ AKALQ 86_ VWPLI 91_ EKRTC 96_ WHGHA 101_ GGGLH 106_ TDPKE 111_ GLKDV 116_ DTRKI 121_ IKAML 126_ SYVWP 131_ KDRPD 136_ LRARV 141_ AISLG 146_ FLGGA 151_ KAMNI 156_ VVPFM 161_ FKYAV 166_ DSLNQ 171_ MSGNM 176_ LNLSD 181_ APNTV 186_ ATMAT 191_ AVLIG 196_ YGVSR 201_ AGAAF 206_ FNEVR 211_ NAVFG 216_ KVAQN 221_ SIRRI 226_ AKNVF 231_ LHLHN 236_ LDLGF 241_ HLSRQ 246_ TGALS 251_ KAIDR 256_ GTRGI 261_ SFVLS 266_ ALVFN 271_ LLPIM 276_ FEVML 281_ VSGVL 286_ YYKCG 291_ AQFAL 296_ VTLGT 301_ LGTYT 306_ AFTVA 311_ VTRWR 316_ TRFRI 321_ EMNKA 326_ DNDAG 331_ NAAID 336_ SLLNY 341_ ETVKY 346_ FNNER 351_ YEAQR 356_ YDGFL 361_ KTYET 366_ ASLKS 371_ TSTLA 376_ MLNFG 381_ QSAIF 386_ SVGLT 391_ AIMVL 396_ ASQGI 401_ VAGTL 406_ TVGDL 411_ VMVNG 416_ LLFQL 421_ SLPLN 426_ FLGTV 431_ YRETR 436_ QALID 441_ MNTLF 446_ TLLKV 451_ DTQIK 456_ DKVMA 461_ SPLQI 466_ TPQTA 471_ TVAFD 476_ NVHFE 481_ YIEGQ 486_ KVLSG 491_ ISFEV 496_ PAGKK 501_ VAIVG 506_ GSGSG 511_ KSTIV 516_ RLLFR 521_ FYEPQ 526_ KGSIY 531_ LAGQN 536_ IQDVS 541_ LESLR 546_ RAVGV 551_ VPQDA 556_ VLFHN 561_ TIYYN 566_ LLYGN 571_ ISASP 576_ EEVYA 581_ VAKLA 586_ GLHDA 591_ ILRMP 596_ HGYDT 601_ QVGER 606_ GLKLS 611_ GGEKQ 616_ RVAIA 621_ RAILK 626_ DPPVI 631_ LYDEA 636_ TSSLD 641_ SITEE 646_ TILGA 651_ MKDVV 656_ KHRTS 661_ IFIAH 666_ RLSTV 671_ VDADE 676_ IIVLD 681_ QGKVA 686_ ERGTH 691_ HGLLA 696_ NPHSI 701_ YSEMW 706_ HTQSS 711_ RVQNH 716_ DNPKW 721_ EAKKE 726_ NISKE 731_ EERKK 736_ LQEEI 741_ VNSVK 746_GCGNC
1: Exports glutathione-coordinated iron-sulfur clusters such as [2Fe-2S]-(GS)4 cluster from the mitochondria to the cytosol in an ATP-dependent manner allowing the assembly of the cytosolic iron-sulfur (Fe/S) cluster-containing proteins and participates in iron homeostasis (PubMed:10196363, PubMed:17192393, PubMed:33157103). Moreover, through a functional complex formed of ABCB7, FECH and ABCB10, also plays a role in the cellular iron homeostasis, mitochondrial function and heme biosynthesis (PubMed:30765471). In cardiomyocytes, regulates cellular iron homeostasis and cellular reactive oxygen species (ROS) levels through its interaction with COX4I1 (By similarity). May also play a role in hematopoiesis (By similarity)