SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34)
1_MTSPA 6_ KFKKD 11_ KEIIA 16_ EYDTQ 21_ VKEIR 26_ AQLTE 31_ QMKCL 36_ DQQCE 41_ LRVQL 46_ LQDLQ 51_ DFFRK 56_ KAEIE 61_ MDYSR 66_ NLEKL 71_ AERFL 76_ AKTRS 81_ TKDQQ 86_ FKKDQ 91_ NVLSP 96_ VNCWN 101_ LLLNQ 106_ VKRES 111_ RDHTT 116_ LSDIY 121_ LNNII 126_ PRFVQ 131_ VSEDS 136_ GRLFK 141_ KSKEV 146_ GQQLQ 151_ DDLMK 156_ VLNEL 161_ YSVMK 166_ TYHMY 171_ NADSI 176_ SAQSK 181_ LKEAE 186_ KQEEK 191_ QIGKS 196_ VKQED 201_ RQTPR 206_ SPDST 211_ ANVRI 216_ EEKHV 221_ RRSSV 226_ KKIEK 231_ MKEKR 236_ QAKYT 241_ ENKLK 246_ AIKAR 251_ NEYLL 256_ ALEAT 261_ NASVF 266_ KYYIH 271_ DLSDL 276_ IDQCC 281_ DLGYH 286_ ASLNR 291_ ALRTF 296_ LSAEL 301_ NLEQS 306_ KHEGL 311_ DAIEN 316_ AVENL 321_ DATSD 326_ KQRLM 331_ EMYNN 336_ VFCPP 341_ MKFEF 346_ QPHMG 351_ DMASQ 356_ LCAQQ 361_ PVQSE 366_ LVQRC 371_ QQLQS 376_ RLSTL 381_ KIENE 386_ EVKKT 391_ MEATL 396_ QTIQD 401_ IVTVE 406_ DFDVS 411_ DCFQY 416_ SNSME 421_ SVKST 426_ VSETF 431_ MSKPS 436_ IAKRR 441_ ANQQE 446_ TEQFY 451_ FTKMK 456_ EYLEG 461_ RNLIT 466_ KLQAK 471_ HDLLQ 476_ KTLGE 481_ SQRTD 486_ CSLAR 491_ RSSTV 496_ RKQDS 501_ SQAIP 506_ LVVES 511_ CIRFI 516_ SRHGL 521_ QHEGI 526_ FRVSG 531_ SQVEV 536_ NDIKN 541_ AFERG 546_ EDPLA 551_ GDQND 556_ HDMDS 561_ IAGVL 566_ KLYFR 571_ GLEHP 576_ LFPKD 581_ IFHDL 586_ MACVT 591_ MDNLQ 596_ ERALH 601_ IRKVL 606_ LVLPK 611_ TTLII 616_ MRYLF 621_ AFLNH 626_ LSQFS 631_ EENMM 636_ DPYNL 641_ AICFG 646_ PSLMS 651_ VPEGH 656_ DQVSC 661_ QAHVN 666_ ELIKT 671_ IIIQH 676_ ENIFP 681_ SPREL 686_ EGPVY 691_ SRGGS 696_ MEDYC 701_ DSPHG 706_ ETTSV 711_ EDSTQ 716_ DVTAE 721_ HHTSD 726_ DECEP 731_ IEAIA 736_ KFDYV 741_ GRTAR 746_ ELSFK 751_ KGASL 756_ LLYQR 761_ ASDDW 766_ WEGRH 771_ NGIDG 776_ LIPHQ 781_ YIVVQ 786_ DTEDG 791_ VVERS 796_ SPKSE 801_ IEVIS 806_ EPPEE 811_ KVTAR 816_ AGASC 821_ PSGGH 826_ VADIY 831_ LANIN 836_ KQRKR 841_ PESGS 846_ IRKTF 851_ RSDSH 856_ GLSSS 861_ LTDSS 866_ SPGVG 871_ ASCRP 876_ SSQPI 881_ MSQSL 886_ PKEGP 891_ DKCSI 896_ SGHGS 901_ LNSIS 906_ RHSSL 911_ KNRLD 916_ SPQIR 921_ KTATA 926_ GRSKS 931_ FNNHR 936_ PMDPE 941_ VIAQD 946_ IEATM 951_ NSALN 956_ ELREL 961_ ERQSS 966_ VKHTP 971_ DVVLD 976_ TLEPL 981_ KTSPV 986_ VAPTS 991_ EPSSP 996_ LHTQL 1001_ LKDPE 1006_ PAFQR 1011_ SASTA 1016_ GDIAC 1021_ AFRPV 1026_ KSVKM 1031_ AAPVK 1036_ PPATR 1041_ PKPTV 1046_ FPKTN 1051_ ATSPG 1056_ VNSST 1061_ SPQST 1066_DKSCT
1: Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex (PubMed:20810653, PubMed:27373832, PubMed:28333212). Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832). SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses (By similarity). Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation (PubMed:27373832). Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions (By similarity). In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia (PubMed:20810653, PubMed:21148482)