Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C-terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein)
1_MPSKT 6_ KYNLV 11_ DDGHD 16_ LRIPL 21_ HNEDA 26_ FQHGI 31_ CFEAK 36_ YVGSL 41_ DVPRP 46_ NSRVE 51_ IVAAM 56_ RRIRY 61_ EFKAK 66_ NIKKK 71_ KVSIM 76_ VSVDG 81_ VKVIL 86_ KKKKK 91_ LLLLQ 96_ KKEWT 101_ WDESK 106_ MLVMQ 111_ DPIYR 116_ IFYVS 121_ HDSQD 126_ LKIFS 131_ YIARD 136_ GASNI 141_ FRCNV 146_ FKSKK 151_ KSQAM 156_ RIVRT 161_ VGQAF 166_ EVCHK 171_ LSLQH 176_ TQQNA 181_ DGQED 186_ GESER 191_ NSNSS 196_ GDPGR 201_ QLTGA 206_ ERAST 211_ ATAEE 216_ TDIDA 221_ VEVPL 226_ PGNDV 231_ LEFSR 236_ GVTDL 241_ DAVGK 246_ EGGSH 251_ TGSKV 256_ SHPQE 261_ PMLTA 266_ SPRML 271_ LPSSS 276_ SKPPG 281_ LGTET 286_ PLSTH 291_ HQMQL 296_ LQQLL 301_ QQQQQ 306_ QTQVA 311_ VAQVH 316_ LLKDQ 321_ LAAEA 326_ AARLE 331_ AQARV 336_ HQLLL 341_ QNKDM 346_ LQHIS 351_ LLVKQ 356_ VQELE 361_ LKLSG 366_ QNAMG 371_ SQDSL 376_ LEITF 381_ RSGAL 386_ PVLCD 391_ PTTPK 396_ PEDLH 401_ SPPLG 406_ AGLAD 411_ FAHPA 416_ GSPLG 421_ RRDCL 426_ VKLEC 431_ FRFLP 436_ PEDTP 441_ PPAQG 446_ EALLG 451_ GLELI 456_ KFRES 461_ GIASE 466_ YESNT 471_ DESEE 476_ RDSWS 481_ QEELP 486_ RLLNV 491_ LQRQE 496_ LGDGL 501_DDEIA
1: Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity). In kidney podocytes, plays a role in podosomes and filopodia formation through CDC42 activation (PubMed:33523862)