Protein CBFA2T3 (MTG8-related protein 2) (Myeloid translocation gene on chromosome 16 protein) (hMTG16) (Zinc finger MYND domain-containing protein 4)
1_MPASR 6_ LRDRA 11_ ASSAS 16_ GSTCG 21_ SMSQT 26_ HPVLE 31_ SGLLA 36_ SAGCS 41_ APRGP 46_ RKGGP 51_ APVDR 56_ KAKAS 61_ AMPDS 66_ PAEVK 71_ TQPRS 76_ TPPSM 81_ PPPPP 86_ AASQG 91_ ATRPP 96_ SFTPH 101_ THRED 106_ GPATL 111_ PHGRF 116_ HGCLK 121_ WSMVC 126_ LLMNG 131_ SSHSP 136_ TAING 141_ APCTP 146_ NGFSN 151_ GPATS 156_ STASL 161_ STQHL 166_ PPACG 171_ ARQLS 176_ KLKRF 181_ LTTLQ 186_ QFGSD 191_ ISPEI 196_ GERVR 201_ TLVLG 206_ LVNST 211_ LTIEE 216_ FHSKL 221_ QEATN 226_ FPLRP 231_ FVIPF 236_ LKANL 241_ PLLQR 246_ ELLHC 251_ ARLAK 256_ QTPAQ 261_ YLAQH 266_ EQLLL 271_ DASAS 276_ SPIDS 281_ SELLL 286_ EVNEN 291_ GKRRT 296_ PDRTK 301_ ENGSD 306_ RDPLH 311_ PEHLS 316_ KRPCT 321_ LNPAQ 326_ RYSPS 331_ NGPPQ 336_ PTPPP 341_ HYRLE 346_ DIAMA 351_ HHFRD 356_ AYRHP 361_ DPREL 366_ RERHR 371_ PLVVP 376_ GSRQE 381_ EVIDH 386_ KLTER 391_ EWAEE 396_ WKHLN 401_ NLLNC 406_ IMDMV 411_ EKTRR 416_ SLTVL 421_ RRCQE 426_ ADREE 431_ LNHWA 436_ RRYSD 441_ AEDTK 446_ KGPAP 451_ AAARP 456_ RSSSA 461_ GPEGP 466_ QLDVP 471_ REFLP 476_ RTLTG 481_ YVPED 486_ IWRKA 491_ EEAVN 496_ EVKRQ 501_ AMSEL 506_ QKAVS 511_ DAERK 516_ AHELI 521_ TTERA 526_ KMERA 531_ LAEAK 536_ RQASE 541_ DALTV 546_ INQQE 551_ DSSES 556_ CWNCG 561_ RKASE 566_ TCSGC 571_ NAARY 576_ CGSFC 581_ QHRDW 586_ EKHHH 591_ VCGQS 596_ LQGPT 601_ AVVAD 606_ PVPGP 611_ PEAAH 616_ SLGPS 621_ LPVGA 626_ ASPSE 631_ AGSAG 636_ PSRPG 641_ SPSPP 646_GPLDT
1: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway (PubMed:25974097). Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A (PubMed:23840896, PubMed:25974097). Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Plays a role in granulocyte differentiation (PubMed:15231665)
2: Isoform 2 functions as an A-kinase-anchoring protein (PubMed:11823486)