Frizzled-7 (Fz-7) (hFz7) (FzE3)
1_MRDPG 6_ AAAPL 11_ SSLGL 16_ CALVL 21_ ALLGA 26_ LSAGA 31_ GAQPY 36_ HGEKG 41_ ISVPD 46_ HGFCQ 51_ PISIP 56_ LCTDI 61_ AYNQT 66_ ILPNL 71_ LGHTN 76_ QEDAG 81_ LEVHQ 86_ FYPLV 91_ KVQCS 96_ PELRF 101_ FLCSM 106_ YAPVC 111_ TVLDQ 116_ AIPPC 121_ RSLCE 126_ RARQG 131_ CEALM 136_ NKFGF 141_ QWPER 146_ LRCEN 151_ FPVHG 156_ AGEIC 161_ VGQNT 166_ SDGSG 171_ GPGGG 176_ PTAYP 181_ TAPYL 186_ PDLPF 191_ TALPP 196_ GASDG 201_ RGRPA 206_ FPFSC 211_ PRQLK 216_ VPPYL 221_ GYRFL 226_ GERDC 231_ GAPCE 236_ PGRAN 241_ GLMYF 246_ KEEER 251_ RFARL 256_ WVGVW 261_ SVLCC 266_ ASTLF 271_ TVLTY 276_ LVDMR 281_ RFSYP 286_ ERPII 291_ FLSGC 296_ YFMVA 301_ VAHVA 306_ GFLLE 311_ DRAVC 316_ VERFS 321_ DDGYR 326_ TVAQG 331_ TKKEG 336_ CTILF 341_ MVLYF 346_ FGMAS 351_ SIWWV 356_ ILSLT 361_ WFLAA 366_ GMKWG 371_ HEAIE 376_ ANSQY 381_ FHLAA 386_ WAVPA 391_ VKTIT 396_ ILAMG 401_ QVDGD 406_ LLSGV 411_ CYVGL 416_ SSVDA 421_ LRGFV 426_ LAPLF 431_ VYLFI 436_ GTSFL 441_ LAGFV 446_ SLFRI 451_ RTIMK 456_ HDGTK 461_ TEKLE 466_ KLMVR 471_ IGVFS 476_ VLYTV 481_ PATIV 486_ LACYF 491_ YEQAF 496_ REHWE 501_ RTWLL 506_ QTCKS 511_ YAVPC 516_ PPGHF 521_ PPMSP 526_ DFTVF 531_ MIKYL 536_ MTMIV 541_ GITTG 546_ FWIWS 551_ GKTLQ 556_ SWRRF 561_ YHRLS 566_HSSKG
1: Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by WNT8 induces expression of beta-catenin target genes (By similarity). Following ligand activation, binds to CCDC88C/DAPLE which displaces DVL1 from FZD7 and leads to inhibition of canonical Wnt signaling, activation of G-proteins by CCDC88C and triggering of non-canonical Wnt responses (PubMed:26126266). May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues
2: (Microbial infection) Acts as a receptor for C.difficile toxin TcdB in the colonic epithelium