Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7)
1_MRRQW 6_ GALLL 11_ GALLC 16_ AHGLA 21_ SSPEC 26_ ACGRS 31_ HFTCA 36_ VSALG 41_ ECTCI 46_ PAQWQ 51_ CDGDN 56_ DCGDH 61_ SDEDG 66_ CILPT 71_ CSPLD 76_ FHCDN 81_ GKCIR 86_ RSWVC 91_ DGDND 96_ CEDDS 101_ DEQDC 106_ PPREC 111_ EEDEF 116_ PCQNG 121_ YCIRS 126_ LWHCD 131_ GDNDC 136_ GDNSD 141_ EQCDM 146_ RKCSD 151_ KEFRC 156_ SDGSC 161_ IAEHW 166_ YCDGD 171_ TDCKD 176_ GSDEE 181_ NCPSA 186_ VPAPP 191_ CNLEE 196_ FQCAY 201_ GRCIL 206_ DIYHC 211_ DGDDD 216_ CGDWS 221_ DESDC 226_ SSHQP 231_ CRSGE 236_ FMCDS 241_ GLCIN 246_ AGWRC 251_ DGDAD 256_ CDDQS 261_ DERNC 266_ TTSMC 271_ TAEQF 276_ RCHSG 281_ RCVRL 286_ SWRCD 291_ GEDDC 296_ ADNSD 301_ EENCE 306_ NTGSP 311_ QCALD 316_ QFLCW 321_ NGRCI 326_ GQRKL 331_ CNGVN 336_ DCGDN 341_ SDESP 346_ QQNCR 351_ PRTGE 356_ ENCNV 361_ NNGGC 366_ AQKCQ 371_ MVRGA 376_ VQCTC 381_ HTGYR 386_ LTEDG 391_ HTCQD 396_ VNECA 401_ EEGYC 406_ SQGCT 411_ NSEGA 416_ FQCWC 421_ ETGYE 426_ LRPDR 431_ RSCKA 436_ LGPEP 441_ VLLFA 446_ NRIDI 451_ RQVLP 456_ HRSEY 461_ TLLLN 466_ NLENA 471_ IALDF 476_ HHRRE 481_ LVFWS 486_ DVTLD 491_ RILRA 496_ NLNGS 501_ NVEEV 506_ VSTGL 511_ ESPGG 516_ LAVDW 521_ VHDKL 526_ YWTDS 531_ GTSRI 536_ EVANL 541_ DGAHR 546_ KVLLW 551_ QNLEK 556_ PRAIA 561_ LHPME 566_ GTIYW 571_ TDWGN 576_ TPRIE 581_ ASSMD 586_ GSGRR 591_ IIADT 596_ HLFWP 601_ NGLTI 606_ DYAGR 611_ RMYWV 616_ DAKHH 621_ VIERA 626_ NLDGS 631_ HRKAV 636_ ISQGL 641_ PHPFA 646_ ITVFE 651_ DSLYW 656_ TDWHT 661_ KSINS 666_ ANKFT 671_ GKNQE 676_ IIRNK 681_ LHFPM 686_ DIHTL 691_ HPQRQ 696_ PAGKN 701_ RCGDN 706_ NGGCT 711_ HLCLP 716_ SGQNY 721_ TCACP 726_ TGFRK 731_ ISSHA 736_ CAQSL 741_ DKFLL 746_ FARRM 751_ DIRRI 756_ SFDTE 761_ DLSDD 766_ VIPLA 771_ DVRSA 776_ VALDW 781_ DSRDD 786_ HVYWT 791_ DVSTD 796_ TISRA 801_ KWDGT 806_ GQEVV 811_ VDTSL 816_ ESPAG 821_ LAIDW 826_ VTNKL 831_ YWTDA 836_ GTDRI 841_ EVANT 846_ DGSMR 851_ TVLIW 856_ ENLDR 861_ PRDIV 866_ VEPMG 871_ GYMYW 876_ TDWGA 881_ SPKIE 886_ RAGMD 891_ ASGRQ 896_ VIISS 901_ NLTWP 906_ NGLAI 911_ DYGSQ 916_ RLYWA 921_ DAGMK 926_ TIEFA 931_ GLDGS 936_ KRKVL 941_ IGSQL 946_ PHPFG 951_ LTLYG 956_ ERIYW 961_ TDWQT 966_ KSIQS 971_ ADRLT 976_ GLDRE 981_ TLQEN 986_ LENLM 991_ DIHVF 996_ HRRRP 1001_ PVSTP 1006_ CAMEN 1011_ GGCSH 1016_ LCLRS 1021_ PNPSG 1026_ FSCTC 1031_ PTGIN 1036_ LLSDG 1041_ KTCSP 1046_ GMNSF 1051_ LIFAR 1056_ RIDIR 1061_ MVSLD 1066_ IPYFA 1071_ DVVVP 1076_ INITM 1081_ KNTIA 1086_ IGVDP 1091_ QEGKV 1096_ YWSDS 1101_ TLHRI 1106_ SRANL 1111_ DGSQH 1116_ EDIIT 1121_ TGLQT 1126_ TDGLA 1131_ VDAIG 1136_ RKVYW 1141_ TDTGT 1146_ NRIEV 1151_ GNLDG 1156_ SMRKV 1161_ LVWQN 1166_ LDSPR 1171_ AIVLY 1176_ HEMGF 1181_ MYWTD 1186_ WGENA 1191_ KLERS 1196_ GMDGS 1201_ DRAVL 1206_ INNNL 1211_ GWPNG 1216_ LTVDK 1221_ ASSQL 1226_ LWADA 1231_ HTERI 1236_ EAADL 1241_ NGANR 1246_ HTLVS 1251_ PVQHP 1256_ YGLTL 1261_ LDSYI 1266_ YWTDW 1271_ QTRSI 1276_ HRADK 1281_ GTGSN 1286_ VILVR 1291_ SNLPG 1296_ LMDMQ 1301_ AVDRA 1306_ QPLGF 1311_ NKCGS 1316_ RNGGC 1321_ SHLCL 1326_ PRPSG 1331_ FSCAC 1336_ PTGIQ 1341_ LKGDG 1346_ KTCDP 1351_ SPETY 1356_ LLFSS 1361_ RGSIR 1366_ RISLD 1371_ TSDHT 1376_ DVHVP 1381_ VPELN 1386_ NVISL 1391_ DYDSV 1396_ DGKVY 1401_ YTDVF 1406_ LDVIR 1411_ RADLN 1416_ GSNME 1421_ TVIGR 1426_ GLKTT 1431_ DGLAV 1436_ DWVAR 1441_ NLYWT 1446_ DTGRN 1451_ TIEAS 1456_ RLDGS 1461_ CRKVL 1466_ INNSL 1471_ DEPRA 1476_ IAVFP 1481_ RKGYL 1486_ FWTDW 1491_ GHIAK 1496_ IERAN 1501_ LDGSE 1506_ RKVLI 1511_ NTDLG 1516_ WPNGL 1521_ TLDYD 1526_ TRRIY 1531_ WVDAH 1536_ LDRIE 1541_ SADLN 1546_ GKLRQ 1551_ VLVSH 1556_ VSHPF 1561_ ALTQQ 1566_ DRWIY 1571_ WTDWQ 1576_ TKSIQ 1581_ RVDKY 1586_ SGRNK 1591_ ETVLA 1596_ NVEGL 1601_ MDIIV 1606_ VSPQR 1611_ QTGTN 1616_ ACGVN 1621_ NGGCT 1626_ HLCFA 1631_ RASDF 1636_ VCACP 1641_ DEPDS 1646_ RPCSL 1651_ VPGLV 1656_ PPAPR 1661_ ATGMS 1666_ EKSPV 1671_ LPNTP 1676_ PTTLY 1681_ SSTTR 1686_ TRTSL 1691_ EEVEG 1696_ RCSER 1701_ DARLG 1706_ LCARS 1711_ NDAVP 1716_ AAPGE 1721_ GLHIS 1726_ YAIGG 1731_ LLSIL 1736_ LILVV 1741_ IAALM 1746_ LYRHK 1751_ KSKFT 1756_ DPGMG 1761_ NLTYS 1766_ NPSYR 1771_ TSTQE 1776_ VKIEA 1781_ IPKPA 1786_ MYNQL 1791_ CYKKE 1796_ GGPDH 1801_ NYTKE 1806_ KIKIV 1811_ EGICL 1816_ LSGDD 1821_ AEWDD 1826_ LKQLR 1831_ SSRGG 1836_ LLRDH 1841_ VCMKT 1846_ DTVSI 1851_ QASSG 1856_ SLDDT 1861_ ETEQL 1866_ LQEEQ 1871_ SECSS 1876_ VHTAA 1881_ TPERR 1886_ GSLPD 1891_ TGWKH 1896_ERKLS
1: Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. May play an essential role in the process of digit differentiation (By similarity)