Probable phospholipid-transporting ATPase IIA (EC 7.6.2.1) (ATPase class II type 9A)
1_MTDNI 6_ PLQPV 11_ RQKKR 16_ MDSRP 21_ RAGCC 26_ EWLRC 31_ CGGGE 36_ ARPRT 41_ VWLGH 46_ PEKRD 51_ QRYPR 56_ NVINN 61_ QKYNF 66_ FTFLP 71_ GVLFN 76_ QFKYF 81_ FNLYF 86_ LLLAC 91_ SQFVP 96_ EMRLG 101_ ALYTY 106_ WVPLG 111_ FVLAV 116_ TVIRE 121_ AVEEI 126_ RCYVR 131_ DKEVN 136_ SQVYS 141_ RLTAR 146_ GTVKV 151_ KSSNI 156_ QVGDL 161_ IIVEK 166_ NQRVP 171_ ADMIF 176_ LRTSE 181_ KNGSC 186_ FLRTD 191_ QLDGE 196_ TDWKL 201_ RLPVA 206_ CTQRL 211_ PTAAD 216_ LLQIR 221_ SYVYA 226_ EEPNI 231_ DIHNF 236_ VGTFT 241_ REDSD 246_ PPISE 251_ SLSIE 256_ NTLWA 261_ GTVVA 266_ SGTVV 271_ GVVLY 276_ TGREL 281_ RSVMN 286_ TSNPR 291_ SKIGL 296_ FDLEV 301_ NCLTK 306_ ILFGA 311_ LVVVS 316_ LVMVA 321_ LQHFA 326_ GRWYL 331_ QIIRF 336_ LLLFS 341_ NIIPI 346_ SLRVN 351_ LDMGK 356_ IVYSW 361_ VIRRD 366_ SKIPG 371_ TVVRS 376_ STIPE 381_ QLGRI 386_ SYLLT 391_ DKTGT 396_ LTQNE 401_ MIFKR 406_ LHLGT 411_ VAYGL 416_ DSMDE 421_ VQSHI 426_ FSIYT 431_ QQSQD 436_ PPAQK 441_ GPTLT 446_ TKVRR 451_ TMSSR 456_ VHEAV 461_ KAIAL 466_ CHNVT 471_ PVYES 476_ NGVTD 481_ QAEAE 486_ KQYED 491_ SCRVY 496_ QASSP 501_ DEVAL 506_ VQWTE 511_ SVGLT 516_ LVGRD 521_ QSSMQ 526_ LRTPG 531_ DQILN 536_ FTILQ 541_ IFPFT 546_ YESKR 551_ MGIIV 556_ RDEST 561_ GEITF 566_ YMKGA 571_ DVVMA 576_ GIVQY 581_ NDWLE 586_ EECGN 591_ MAREG 596_ LRVLV 601_ VAKKS 606_ LAEEQ 611_ YQDFE 616_ ARYVQ 621_ AKLSV 626_ HDRSL 631_ KVATV 636_ IESLE 641_ MEMEL 646_ LCLTG 651_ VEDQL 656_ QADVR 661_ PTLET 666_ LRNAG 671_ IKVWM 676_ LTGDK 681_ LETAT 686_ CTAKN 691_ AHLVT 696_ RNQDI 701_ HVFRL 706_ VTNRG 711_ EAHLE 716_ LNAFR 721_ RKHDC 726_ ALVIS 731_ GDSLE 736_ VCLKY 741_ YEYEF 746_ MELAC 751_ QCPAV 756_ VCCRC 761_ APTQK 766_ AQIVR 771_ LLQER 776_ TGKLT 781_ CAVGD 786_ GGNDV 791_ SMIQE 796_ SDCGV 801_ GVEGK 806_ EGKQA 811_ SLAAD 816_ FSITQ 821_ FKHLG 826_ RLLMV 831_ HGRNS 836_ YKRSA 841_ ALSQF 846_ VIHRS 851_ LCIST 856_ MQAVF 861_ SSVFY 866_ FASVP 871_ LYQGF 876_ LIIGY 881_ STIYT 886_ MFPVF 891_ SLVLD 896_ KDVKS 901_ EVAML 906_ YPELY 911_ KDLLK 916_ GRPLS 921_ YKTFL 926_ IWVLI 931_ SIYQG 936_ STIMY 941_ GALLL 946_ FESEF 951_ VHIVA 956_ ISFTS 961_ LILTE 966_ LLMVA 971_ LTIQT 976_ WHWLM 981_ TVAEL 986_ LSLAC 991_ YIASL 996_ VFLHE 1001_ FIDVY 1006_ FIATL 1011_ SFLWK 1016_ VSVIT 1021_ LVSCL 1026_ PLYVL 1031_ KYLRR 1036_ RFSPP 1041_SYSKL
1: Plays a role in regulating membrane trafficking of cargo proteins, namely endosome to plasma membrane recycling, probably acting through RAB5 and RAB11 activation (PubMed:27733620, PubMed:30213940, PubMed:36604604). Also involved in endosome to trans-Golgi network retrograde transport (PubMed:27733620, PubMed:30213940). In complex with MON2 and DOP1B, regulates SNX3 retromer-mediated endosomal sorting of WLS, a transporter of Wnt morphogens in developing tissues. Participates in the formation of endosomal carriers that direct WLS trafficking back to Golgi, away from lysosomal degradation (PubMed:30213940). Appears to be implicated in intercellular communication by negatively regulating the release of exosomes (PubMed:30947313). The flippase activity towards membrane lipids and its role in membrane asymmetry remains to be proved (PubMed:30947313). Required for the maintenance of neurite morphology and synaptic transmission (By similarity)