NEDD4-binding protein 1 (N4BP1) (EC 3.1.-.-)
1_MAARA 6_ VLDEF 11_ TAPAE 16_ KAELL 21_ EQSRG 26_ RIEGL 31_ FGVSL 36_ AVLGA 41_ LGAEE 46_ PLPAR 51_ IWLQL 56_ CGAQE 61_ AVHSA 66_ KEYIK 71_ GICEP 76_ ELEER 81_ ECYPK 86_ DMHCI 91_ FVGAE 96_ SLFLK 101_ SLIQD 106_ TCADL 111_ CILDI 116_ GLLGI 121_ RGSAE 126_ AVVMA 131_ RSHIQ 136_ QFVKL 141_ FENKE 146_ NLPSS 151_ QKESE 156_ VKREF 161_ KQFVE 166_ AHADN 171_ YTMDL 176_ LILPT 181_ SLKKE 186_ LLTLT 191_ QGEEN 196_ LFETG 201_ DDEVI 206_ EMRDS 211_ QQTEF 216_ TQNAA 221_ TGLNI 226_ SRDET 231_ VLQEE 236_ ARNKA 241_ GTPVS 246_ ELTKQ 251_ MDTVL 256_ SSSPD 261_ VLFDP 266_ INGLT 271_ PDEEA 276_ LSNER 281_ ICQKR 286_ RFSDS 291_ EERHT 296_ KKQFS 301_ LENVQ 306_ EGEIL 311_ HDAKT 316_ LAGNV 321_ IADLS 326_ DSSAD 331_ SENLS 336_ PDIKE 341_ TTEEM 346_ EYNIL 351_ VNFFK 356_ TMGYS 361_ QEIVE 366_ KVIKV 371_ YGPST 376_ EPLLL 381_ LEEIE 386_ KENKR 391_ FQEDR 396_ EFSAG 401_ TVYPE 406_ TNKTK 411_ NKGVY 416_ SSTNE 421_ LTTDS 426_ TPKKT 431_ QAHTQ 436_ QNMVE 441_ KFSQL 446_ PFKVE 451_ AKPCT 456_ SNCRI 461_ NTFRT 466_ VPIEQ 471_ KHEVW 476_ GSNQN 481_ YICNT 486_ DPETD 491_ GLSPS 496_ VASPS 501_ PKEVN 506_ FVSRG 511_ ASSHQ 516_ PRVPL 521_ FPENG 526_ LHQQP 531_ EPLLP 536_ NNMKS 541_ ACEKR 546_ LGCCS 551_ SPHSK 556_ PNCST 561_ LSPPM 566_ PLPQL 571_ LPSVT 576_ DARSA 581_ GPSDH 586_ IDSSV 591_ TGVQR 596_ FRDTL 601_ KIPYK 606_ LELKN 611_ EPGRT 616_ DLKHI 621_ VIDGS 626_ NVAIT 631_ HGLKK 636_ FFSCR 641_ GIAIA 646_ VEYFW 651_ KLGNR 656_ NITVF 661_ VPQWR 666_ TRRDP 671_ NVTEQ 676_ HFLTQ 681_ LQELG 686_ ILSLT 691_ PARMV 696_ FGERI 701_ ASHDD 706_ RFLLH 711_ LADKT 716_ GGIIV 721_ TNDNF 726_ REFVN 731_ ESVSW 736_ REIIT 741_ KRLLQ 746_ YTFVG 751_ DIFMV 756_ PDDPL 761_ GRSGP 766_ RLEEF 771_ LQKEV 776_ CLRDM 781_ QPLLS 786_ ALPNV 791_ GMFDP 796_ SFRVP 801_ GTQAA 806_ STSHQ 811_ PPTRI 816_ QGAPS 821_ SHWLP 826_ QQPHF 831_ PLLPA 836_ LPSLQ 841_ QNLPM 846_ PAQRS 851_ SAETN 856_ ELREA 861_ LLKIF 866_ PDSEQ 871_ RLKID 876_ QILVA 881_ HPYMK 886_ DLNAL 891_SAMVL
1: Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation. Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults. In response to more threatening pathogens, cleaved by CASP8 downstream of TLR3 or TLR4, leading to its inactivation, thereby allowing production of inflammatory cytokines (By similarity). Acts as a restriction factor against some viruses, such as HIV-1: restricts HIV-1 replication by binding to HIV-1 mRNAs and mediating their degradation via its ribonuclease activity (PubMed:31133753). Also acts as an inhibitor of the E3 ubiquitin-protein ligase ITCH: acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (By similarity)