Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2)
1_MSRPP 6_ PTGKM 11_ PGAPE 16_ TAPGD 21_ GAGAS 26_ RQRKL 31_ EALIR 36_ DPRSP 41_ INVES 46_ LLDGL 51_ NSLVL 56_ DLDFP 61_ ALRKN 66_ KNIDN 71_ FLNRY 76_ EKIVK 81_ KIRGL 86_ QMKAE 91_ DYDVV 96_ KVIGR 101_ GAFGE 106_ VQLVR 111_ HKASQ 116_ KVYAM 121_ KLLSK 126_ FEMIK 131_ RSDSA 136_ FFWEE 141_ RDIMA 146_ FANSP 151_ WVVQL 156_ FYAFQ 161_ DDRYL 166_ YMVME 171_ YMPGG 176_ DLVNL 181_ MSNYD 186_ VPEKW 191_ AKFYT 196_ AEVVL 201_ ALDAI 206_ HSMGL 211_ IHRDV 216_ KPDNM 221_ LLDKH 226_ GHLKL 231_ ADFGT 236_ CMKMD 241_ ETGMV 246_ HCDTA 251_ VGTPD 256_ YISPE 261_ VLKSQ 266_ GGDGF 271_ YGREC 276_ DWWSV 281_ GVFLY 286_ EMLVG 291_ DTPFY 296_ ADSLV 301_ GTYSK 306_ IMDHK 311_ NSLCF 316_ PEDAE 321_ ISKHA 326_ KNLIC 331_ AFLTD 336_ REVRL 341_ GRNGV 346_ EEIRQ 351_ HPFFK 356_ NDQWH 361_ WDNIR 366_ ETAAP 371_ VVPEL 376_ SSDID 381_ SSNFD 386_ DIEDD 391_ KGDVE 396_ TFPIP 401_ KAFVG 406_ NQLPF 411_ IGFTY 416_ YRENL 421_ LLSDS 426_ PSCRE 431_ TDSIQ 436_ SRKNE 441_ ESQEI 446_ QKKLY 451_ TLEEH 456_ LSNEM 461_ QAKEE 466_ LEQKC 471_ KSVNT 476_ RLEKT 481_ AKELE 486_ EEITL 491_ RKSVE 496_ SALRQ 501_ LEREK 506_ ALLQH 511_ KNAEY 516_ QRKAD 521_ HEADK 526_ KRNLE 531_ NDVNS 536_ LKDQL 541_ EDLKK 546_ RNQNS 551_ QISTE 556_ KVNQL 561_ QRQLD 566_ ETNAL 571_ LRTES 576_ DTAAR 581_ LRKTQ 586_ AESSK 591_ QIQQL 596_ ESNNR 601_ DLQDK 606_ NCLLE 611_ TAKLK 616_ LEKEF 621_ INLQS 626_ ALESE 631_ RRDRT 636_ HGSEI 641_ INDLQ 646_ GRICG 651_ LEEDL 656_ KNGKI 661_ LLAKV 666_ ELEKR 671_ QLQER 676_ FTDLE 681_ KEKSN 686_ MEIDM 691_ TYQLK 696_ VIQQS 701_ LEQEE 706_ AEHKA 711_ TKARL 716_ ADKNK 721_ IYESI 726_ EEAKS 731_ EAMKE 736_ MEKKL 741_ LEERT 746_ LKQKV 751_ ENLLL 756_ EAEKR 761_ CSLLD 766_ CDLKQ 771_ SQQKI 776_ NELLK 781_ QKDVL 786_ NEDVR 791_ NLTLK 796_ IEQET 801_ QKRCL 806_ TQNDL 811_ KMQTQ 816_ QVNTL 821_ KMSEK 826_ QLKQE 831_ NNHLM 836_ EMKMN 841_ LEKQN 846_ AELRK 851_ ERQDA 856_ DGQMK 861_ ELQDQ 866_ LEAEQ 871_ YFSTL 876_ YKTQV 881_ RELKE 886_ ECEEK 891_ TKLGK 896_ ELQQK 901_ KQELQ 906_ DERDS 911_ LAAQL 916_ EITLT 921_ KADSE 926_ QLARS 931_ IAEEQ 936_ YSDLE 941_ KEKIM 946_ KELEI 951_ KEMMA 956_ RHKQE 961_ LTEKD 966_ ATIAS 971_ LEETN 976_ RTLTS 981_ DVANL 986_ ANEKE 991_ ELNNK 996_ LKDVQ 1001_ EQLSR 1006_ LKDEE 1011_ ISAAA 1016_ IKAQF 1021_ EKQLL 1026_ TERTL 1031_ KTQAV 1036_ NKLAE 1041_ IMNRK 1046_ EPVKR 1051_ GNDTD 1056_ VRRKE 1061_ KENRK 1066_ LHMEL 1071_ KSERE 1076_ KLTQQ 1081_ MIKYQ 1086_ KELNE 1091_ MQAQI 1096_ AEESQ 1101_ IRIEL 1106_ QMTLD 1111_ SKDSD 1116_ IEQLR 1121_ SQLQA 1126_ LHIGL 1131_ DSSSI 1136_ GSGPG 1141_ DAEAD 1146_ DGFPE 1151_ SRLEG 1156_ WLSLP 1161_ VRNNT 1166_ KKFGW 1171_ VKKYV 1176_ IVSSK 1181_ KILFY 1186_ DSEQD 1191_ KEQSN 1196_ PYMVL 1201_ DIDKL 1206_ FHVRP 1211_ VTQTD 1216_ VYRAD 1221_ AKEIP 1226_ RIFQI 1231_ LYANE 1236_ GESKK 1241_ EQEFP 1246_ VEPVG 1251_ EKSNY 1256_ ICHKG 1261_ HEFIP 1266_ TLYHF 1271_ PTNCE 1276_ ACMKP 1281_ LWHMF 1286_ KPPPA 1291_ LECRR 1296_ CHIKC 1301_ HKDHM 1306_ DKKEE 1311_ IIAPC 1316_ KVYYD 1321_ ISTAK 1326_ NLLLL 1331_ ANSTE 1336_ EQQKW 1341_ VSRLV 1346_ KKIPK 1351_ KPPAP 1356_ DPFAR 1361_ SSPRT 1366_ SMKIQ 1371_ QNQSI 1376_ RRPSR 1381_QLAPN
1: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation