ICOS ligand (B7 homolog 2) (B7-H2) (B7-like protein Gl50) (B7-related protein 1) (B7RP-1) (CD antigen CD275)
1_MRLGS 6_ PGLLF 11_ LLFSS 16_ LRADT 21_ QEKEV 26_ RAMVG 31_ SDVEL 36_ SCACP 41_ EGSRF 46_ DLNDV 51_ YVYWQ 56_ TSESK 61_ TVVTY 66_ HIPQN 71_ SSLEN 76_ VDSRY 81_ RNRAL 86_ MSPAG 91_ MLRGD 96_ FSLRL 101_ FNVTP 106_ QDEQK 111_ FHCLV 116_ LSQSL 121_ GFQEV 126_ LSVEV 131_ TLHVA 136_ ANFSV 141_ PVVSA 146_ PHSPS 151_ QDELT 156_ FTCTS 161_ INGYP 166_ RPNVY 171_ WINKT 176_ DNSLL 181_ DQALQ 186_ NDTVF 191_ LNMRG 196_ LYDVV 201_ SVLRI 206_ ARTPS 211_ VNIGC 216_ CIENV 221_ LLQQN 226_ LTVGS 231_ QTGND 236_ IGERD 241_ KITEN 246_ PVSTG 251_ EKNAA 256_ TWSIL 261_ AVLCL 266_ LVVVA 271_ VAIGW 276_ VCRDR 281_ CLQHS 286_ YAGAW 291_ AVSPE 296_TELTG
1: Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion (PubMed:11007762, PubMed:11023515, PubMed:30498080). Also induces B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity). In endothelial cells, required for proper neutrophil transmigration in response to chemoattractants, such as CXCL8/IL8 or N-formyl-methionyl peptides (fMLP) (PubMed:30498080)