E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B)
1_MSGPG 6_ NKRAA 11_ GDGGS 16_ GPPEK 21_ KLSRE 26_ EKTTT 31_ TLIEP 36_ IRLGG 41_ ISSTE 46_ EMDLK 51_ VLQFK 56_ NKKLA 61_ ERLEQ 66_ RQACE 71_ DELRE 76_ RIEKL 81_ EKRQA 86_ TDDAT 91_ LLIVN 96_ RYWAQ 101_ LDETV 106_ EALLR 111_ CHESQ 116_ GELSS 121_ APEAP 126_ GTQEG 131_ PTCDG 136_ TPLPE 141_ PGTSE 146_ LRDPL 151_ LMQLR 156_ PPLSE 161_ PALAF 166_ VVALG 171_ ASSSE 176_ EVELE 181_ LQGRM 186_ EFSKA 191_ AVSRV 196_ VEASD 201_ RLQRR 206_ VEELC 211_ QRVYS 216_ RGDSE 221_ PLSEA 226_ AQAHT 231_ RELGR 236_ ENRRL 241_ QDLAT 246_ QLQEK 251_ HHRIS 256_ LEYSE 261_ LQDKV 266_ TSAET 271_ KVLEM 276_ ETTVE 281_ DLQWD 286_ IEKLR 291_ KREQK 296_ LNKHL 301_ AEALE 306_ QLNSG 311_ YYVSG 316_ SSSGF 321_ QGGQI 326_ TLSMQ 331_ KFEML 336_ NAELE 341_ ENQEL 346_ ANSRM 351_ AELEK 356_ LQAEL 361_ QGAVR 366_ TNERL 371_ KVALR 376_ SLPEE 381_ VVRET 386_ GEYRM 391_ LQAQF 396_ SLLYN 401_ ESLQV 406_ KTQLD 411_ EARGL 416_ LLATK 421_ NSHLR 426_ HIEHM 431_ ESDEL 436_ GLQKK 441_ LRTEV 446_ IQLED 451_ TLAQV 456_ RKEYE 461_ MLRIE 466_ FEQNL 471_ AANEQ 476_ AGPIN 481_ REMRH 486_ LISSL 491_ QNHNH 496_ QLKGD 501_ AQRYK 506_ RKLRE 511_ VQAEI 516_ GKLRA 521_ QASGS 526_ AHSTP 531_ NLGHP 536_ EDSGV 541_ SAPAP 546_ GKEEG 551_ GPGPV 556_ STPDN 561_ RKEMA 566_ PVPGT 571_ TTTTT 576_ SVKKE 581_ ELVPS 586_ EEDFQ 591_ GITPG 596_ AQGPS 601_ SRGRE 606_ PEARP 611_ KRELR 616_ EREGP 621_ SLGPP 626_ PVASA 631_ LSRAD 636_ REKAK 641_ VEETK 646_ RKESE 651_ LLKGL 656_ RAELK 661_ KAQES 666_ QKEMK 671_ LLLDM 676_ YKSAP 681_ KEQRD 686_ KVQLM 691_ AAERK 696_ AKAEV 701_ DELRS 706_ RIREL 711_ EERDR 716_ RESKK 721_ IADED 726_ ALRRI 731_ RQAEE 736_ QIEHL 741_ QRKLG 746_ ATKQE 751_ EEALL 756_ SEMDV 761_ TGQAF 766_ EDMQE 771_ QNGRL 776_ LQQLR 781_ EKDDA 786_ NFKLM 791_ SERIK 796_ ANQIH 801_ KLLRE 806_ EKDEL 811_ GEQVL 816_ GLKSQ 821_ VDAQL 826_ LTVQK 831_ LEEKE 836_ RALQG 841_ SLGGV 846_ EKELT 851_ LRSQA 856_ LELNK 861_ RKAVE 866_ AAQLA 871_ EDLKV 876_ QLEHV 881_ QTRLR 886_ EIQPC 891_ LAESR 896_ AAREK 901_ ESFNL 906_ KRAQE 911_ DISRL 916_ RRKLE 921_ KQRKV 926_ EVYAD 931_ ADEIL 936_ QEEIK 941_ EYKAR 946_ LTCPC 951_ CNTRK 956_ KDAVL 961_ TKCFH 966_ VFCFE 971_ CVRGR 976_ YEARQ 981_ RKCPK 986_ CNAAF 991_ GAHDF 996_HRIYI
1: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes
2: (Microbial infection) Promotes the human herpesvirus 8 (KSHV) lytic cycle by inducing the expression of lytic viral genes including the latency switch gene RTA/ORF50