Lysine-specific demethylase PHF2 (EC 1.14.11.-) (GRC5) (PHD finger protein 2)
1_MATVP 6_ VYCVC 11_ RLPYD 16_ VTRFM 21_ IECDA 26_ CKDWF 31_ HGSCV 36_ GVEEE 41_ EAPDI 46_ DIYHC 51_ PNCEK 56_ THGKS 61_ TLKKK 66_ RTWHK 71_ HGPGQ 76_ APDVK 81_ PVQNG 86_ SQLFI 91_ KELRS 96_ RTFPS 101_ AEDVV 106_ ARVPG 111_ SQLTL 116_ GYMEE 121_ HGFTE 126_ PILVP 131_ KKDGL 136_ GLAVP 141_ APTFY 146_ VSDVE 151_ NYVGP 156_ ERSVD 161_ VTDVT 166_ KQKDC 171_ KMKLK 176_ EFVDY 181_ YYSTN 186_ RKRVL 191_ NVTNL 196_ EFSDT 201_ RMSSF 206_ VEPPD 211_ IVKKL 216_ SWVEN 221_ YWPDD 226_ ALLAK 231_ PKVTK 236_ YCLIC 241_ VKDSY 246_ TDFHI 251_ DSGGA 256_ SAWYH 261_ VLKGE 266_ KTFYL 271_ IRPAS 276_ ANISL 281_ YERWR 286_ SASNH 291_ SEMFF 296_ ADQVD 301_ KCYKC 306_ IVKQG 311_ QTLFI 316_ PSGWI 321_ YATLT 326_ PVDCL 331_ AFAGH 336_ FLHSL 341_ SVEMQ 346_ MRAYE 351_ VERRL 356_ KLGSL 361_ TQFPN 366_ FETAC 371_ WYMGK 376_ HLLEA 381_ FKGSH 386_ KSGKQ 391_ LPPHL 396_ VQGAK 401_ ILNGA 406_ FRSWT 411_ KKQAL 416_ AEHED 421_ ELPEH 426_ FKPSQ 431_ LIKDL 436_ AKEIR 441_ LSENA 446_ SKAVR 451_ PEVNT 456_ VASSD 461_ EVCDG 466_ DREKE 471_ EPPSP 476_ IEATP 481_ PQSLL 486_ EKVSK 491_ KKTPK 496_ TVKMP 501_ KPSKI 506_ PKPPK 511_ PPKPP 516_ RPPKT 521_ LKLKD 526_ GGKKK 531_ GKKSR 536_ ESASP 541_ TIPNL 546_ DLLEA 551_ HTKEA 556_ LTKME 561_ PPKKG 566_ KATKS 571_ VLSVP 576_ NKDVV 581_ HMQND 586_ VERLE 591_ IREQT 596_ KSKSE 601_ AKWKY 606_ KNSKP 611_ DSLLK 616_ MEEEQ 621_ KLEKS 626_ PLAGN 631_ KDNKF 636_ SFSFS 641_ NKKLL 646_ GSKAL 651_ RPPTS 656_ PGVFG 661_ ALQNF 666_ KEDKP 671_ KPVRD 676_ EYEYV 681_ SDDGE 686_ LKIDE 691_ FPIRR 696_ KKNAP 701_ KRDLS 706_ FLLDK 711_ KAVLP 716_ TPVTK 721_ PKLDS 726_ AAYKS 731_ DDSSD 736_ EGSLH 741_ IDTDT 746_ KPGRN 751_ ARVKK 756_ ESGSS 761_ AAGIL 766_ DLLQA 771_ SEEVG 776_ ALEYN 781_ PSSQP 786_ PASPS 791_ TQEAI 796_ QGMLS 801_ MANLQ 806_ ASDSC 811_ LQTTW 816_ GAGQA 821_ KGSSL 826_ AAHGA 831_ RKNGG 836_ GSGKS 841_ AGKRL 846_ LKRAA 851_ KNSVD 856_ LDDYE 861_ EEQDH 866_ LDACF 871_ KDSDY 876_ VYPSL 881_ ESDED 886_ NPIFK 891_ SRSKK 896_ RKGSD 901_ DAPYS 906_ PTARV 911_ GPSVP 916_ RQDRP 921_ VREGT 926_ RVASI 931_ ETGLA 936_ AAAAK 941_ LSQQE 946_ EQKSK 951_ KKKSA 956_ KRKLT 961_ PNTTS 966_ PSTST 971_ SISAG 976_ TTSTS 981_ TTPAS 986_ TTPAS 991_ TTPAS 996_ TSTAS 1001_ SQASQ 1006_ EGSSP 1011_ EPPPE 1016_ SHSSS 1021_ LADHE 1026_ YTAAG 1031_ TFTGA 1036_ QAGRT 1041_ SQPMA 1046_ PGVFL 1051_ TQRRP 1056_ SASSP 1061_ NNNTA 1066_ AKGKR 1071_ TKKGM 1076_ ATAKQ 1081_ RLGKI 1086_ LKIHR 1091_NGKLL
1: Lysine demethylase that demethylates both histones and non-histone proteins (PubMed:20129925, PubMed:21167174, PubMed:21532585). Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B (PubMed:21532585). Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes (PubMed:21532585). The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (PubMed:21532585). Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters (By similarity)