Rab11 family-interacting protein 3 (FIP3-Rab11) (Rab11-FIP3) (Arfophilin-1) (EF hands-containing Rab-interacting protein) (Eferin) (MU-MB-17.148)
1_MASAP 6_ PASPP 11_ GSEPP 16_ GPDPE 21_ PGGPD 26_ GPGAA 31_ QLAPG 36_ PAELR 41_ LGAPV 46_ GGPDP 51_ QSPGL 56_ DEPAP 61_ GAAAD 66_ GGARW 71_ SAGPA 76_ PGLEG 81_ GPRDP 86_ GPSAP 91_ PPRSG 96_ PRGQL 101_ ASPDA 106_ PGPGP 111_ RSEAP 116_ LPELD 121_ PLFSW 126_ TEEPE 131_ ECGPA 136_ SCPES 141_ APFRL 146_ QGSSS 151_ SHRAR 156_ GEVDV 161_ FSPFP 166_ APTAG 171_ ELALE 176_ QGPGS 181_ PPQPS 186_ DLSQT 191_ HPLPS 196_ EPVGS 201_ QEDGP 206_ RLRAV 211_ FDALD 216_ GDGDG 221_ FVRIE 226_ DFIQF 231_ ATVYG 236_ AEQVK 241_ DLTKY 246_ LDPSG 251_ LGVIS 256_ FEDFY 261_ QGITA 266_ IRNGD 271_ PDGQC 276_ YGGVA 281_ SAQDE 286_ EPLAC 291_ PDEFD 296_ DFVTY 301_ EANEV 306_ TDSAY 311_ MGSES 316_ TYSEC 321_ ETFTD 326_ EDTST 331_ LVHPE 336_ LQPEG 341_ DADSA 346_ GGSAV 351_ PSECL 356_ DAMEE 361_ PDHGA 366_ LLLLP 371_ GRPHP 376_ HGQSV 381_ ITVIG 386_ GEEHF 391_ EDYGE 396_ GSEAE 401_ LSPET 406_ LCNGQ 411_ LGCSD 416_ PAFLT 421_ PSPTK 426_ RLSSK 431_ KVARY 436_ LHQSG 441_ ALTME 446_ ALEDP 451_ SPELM 456_ EGPEE 461_ DIADK 466_ VVFLE 471_ RRVLE 476_ LEKDT 481_ AATGE 486_ QHSRL 491_ RQENL 496_ QLVHR 501_ ANALE 506_ EQLKE 511_ QELRA 516_ CEMVL 521_ EETRR 526_ QKELL 531_ CKMER 536_ EKSIE 541_ IENLQ 546_ TRLQQ 551_ LDEEN 556_ SELRS 561_ CTPCL 566_ KANIE 571_ RLEEE 576_ KQKLL 581_ DEIES 586_ LTLRL 591_ SEEQE 596_ NKRRM 601_ GDRLS 606_ HERHQ 611_ FQRDK 616_ EATQE 621_ LIEDL 626_ RKQLE 631_ HLQLL 636_ KLEAE 641_ QRRGR 646_ SSSMG 651_ LQEYH 656_ SRARE 661_ SELEQ 666_ EVRRL 671_ KQDNR 676_ NLKEQ 681_ NEELN 686_ GQIIT 691_ LSIQG 696_ AKSLF 701_ STAFS 706_ ESLAA 711_ EISSV 716_ SRDEL 721_ MEAIQ 726_ KQEEI 731_ NFRLQ 736_ DYIDR 741_ IIVAI 746_ METNP 751_SILEV
1: Downstream effector molecule for Rab11 GTPase which is involved in endocytic trafficking, cytokinesis and intracellular ciliogenesis by participating in membrane delivery (PubMed:15601896, PubMed:16148947, PubMed:17394487, PubMed:17628206, PubMed:18511905, PubMed:19327867, PubMed:20026645, PubMed:25673879, PubMed:26258637, PubMed:31204173). Recruited by Rab11 to endosomes where it links Rab11 to dynein motor complex (PubMed:20026645). The functional Rab11-RAB11FIP3-dynein complex regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endocytic recycling compartment (ERC) during interphase of cell cycle (PubMed:17394487, PubMed:20026645). Facilitates the interaction between dynein and dynactin and activates dynein processivity (PubMed:25035494). Binding with ASAP1 is needed to regulate the pericentrosomal localization of recycling endosomes (By similarity). The Rab11-RAB11FIP3 complex is also implicated in the transport during telophase of vesicles derived from recycling endosomes to the cleavage furrow via centrosome-anchored microtubules, where the vesicles function to deliver membrane during late cytokinesis and abscission (PubMed:15601896, PubMed:16148947). The recruitment of Rab11-RAB11FIP3-containing endosomes to the cleavage furrow and tethering to the midbody is co-mediated by RAB11FIP3 interaction with ARF6-exocyst and RACGAP1-MKLP1 tethering complexes (PubMed:17628206, PubMed:18511905). Also involved in the Rab11-Rabin8-Rab8 ciliogenesis cascade by facilitating the orderly assembly of a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which directs preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:26258637, PubMed:31204173). Also promotes the activity of Rab11 and ASAP1 in the ARF4-dependent Golgi-to-cilia transport of the sensory receptor rhodopsin (PubMed:25673879). Competes with WDR44 for binding to Rab11, which controls intracellular ciliogenesis pathway (PubMed:31204173). May play a role in breast cancer cell motility by regulating actin cytoskeleton (PubMed:19327867)