Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2 protein 6) (CIS-6) (Cytokine-inducible SH2-containing protein 5)
1_MDKVG 6_ KMWNN 11_ FKYRC 16_ QNLFG 21_ HEGGS 26_ RSENV 31_ DMNSN 36_ RCLSV 41_ KEKNI 46_ SIGDS 51_ TPQQQ 56_ SSPLR 61_ ENIAL 66_ QLGLS 71_ PSKNS 76_ SRRNQ 81_ NCATE 86_ IPQIV 91_ EISIE 96_ KDNDS 101_ CVTPG 106_ TRLAR 111_ RDSYS 116_ RHAPW 121_ GGKKK 126_ HSCST 131_ KTQSS 136_ LDADK 141_ KFGRT 146_ RSGLQ 151_ RRERR 156_ YGVSS 161_ VHDMD 166_ SVSSR 171_ TVGSR 176_ SLRQR 181_ LQDTV 186_ GLCFP 191_ MRTYS 196_ KQSKP 201_ LFSNK 206_ RKIHL 211_ SELML 216_ EKCPF 221_ PAGSD 226_ LAQKW 231_ HLIKQ 236_ HTAPV 241_ SPHST 246_ FFDTF 251_ DPSLV 256_ STEDE 261_ EDRLR 266_ ERRRL 271_ SIEEG 276_ VDPPP 281_ NAQIH 286_ TFEAT 291_ AQVNP 296_ LYKLG 301_ PKLAP 306_ GMTEI 311_ SGDSS 316_ AIPQA 321_ NCDSE 326_ EDTTT 331_ LCLQS 336_ RRQKQ 341_ RQISG 346_ DSHTH 351_ VSRQG 356_ AWKVH 361_ TQIDY 366_ IHCLV 371_ PDLLQ 376_ ITGNP 381_ CYWGV 386_ MDRYE 391_ AEALL 396_ EGKPE 401_ GTFLL 406_ RDSAQ 411_ EDYLF 416_ SVSFR 421_ RYNRS 426_ LHARI 431_ EQWNH 436_ NFSFD 441_ AHDPC 446_ VFHSS 451_ TVTGL 456_ LEHYK 461_ DPSSC 466_ MFFEP 471_ LLTIS 476_ LNRTF 481_ PFSLQ 486_ YICRA 491_ VICRC 496_ TTYDG 501_ IDGLP 506_ LPSML 511_ QDFLK 516_ EYHYK 521_ QKVRV 526_ RWLER 531_EPVKA
1: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling