Nephrocystin-4 (Nephroretinin)
1_MNDWH 6_ RIFTQ 11_ NVLVP 16_ PHPQR 21_ ARQPW 26_ KESTA 31_ FQCVL 36_ KWLDG 41_ PVIRQ 46_ GVLEV 51_ LSEVE 56_ CHLRV 61_ SFFDV 66_ TYRHF 71_ FGRTW 76_ KTTVK 81_ PTKRP 86_ PSRIV 91_ FNEPL 96_ YFHTS 101_ LNHPH 106_ IVAVV 111_ EVVAE 116_ GKKRD 121_ GSLQT 126_ LSCGF 131_ GILRI 136_ FSNQP 141_ DSPIS 146_ ASQDK 151_ RLRLY 156_ HGTPR 161_ ALLHP 166_ LLQDP 171_ AEQNR 176_ HMTLI 181_ ENCSL 186_ QYTLK 191_ PHPAL 196_ EPAFH 201_ LLPEN 206_ LLVSG 211_ LQQIP 216_ GLLPA 221_ HGESG 226_ DALRK 231_ PRLQK 236_ PITGH 241_ LDDLF 246_ FTLYP 251_ SLEKF 256_ EEELL 261_ ELHVQ 266_ DHFQE 271_ GCGPL 276_ DGGAL 281_ EILER 286_ RLRVG 291_ VHNGL 296_ GFVQR 301_ PQVVV 306_ LVPEM 311_ DVALT 316_ RSASF 321_ SRKVV 326_ SSSKT 331_ SSGSQ 336_ ALVLR 341_ SRLRL 346_ PEMVG 351_ HPAFA 356_ VIFQL 361_ EYVFS 366_ SPAGV 371_ DGNAA 376_ SVTSL 381_ SNLAC 386_ MHMVR 391_ WAVWN 396_ PLLEA 401_ DSGRV 406_ TLPLQ 411_ GGIQP 416_ NPSHC 421_ LVYKV 426_ PSASM 431_ SSEEV 436_ KQVES 441_ GTLRF 446_ QFSLG 451_ SEEHL 456_ DAPTE 461_ PVSGP 466_ KVERR 471_ PSRKP 476_ PTSPS 481_ SPPAP 486_ VPRVL 491_ AAPQN 496_ SPVGP 501_ GLSIS 506_ QLAAS 511_ PRSPT 516_ QHCLA 521_ RPTSQ 526_ LPHGS 531_ QASPA 536_ QAQEF 541_ PLEAG 546_ ISHLE 551_ ADLSQ 556_ TSLVL 561_ ETSIA 566_ EQLQE 571_ LPFTP 576_ LHAPI 581_ VVGTQ 586_ TRSSA 591_ GQPSR 596_ ASMVL 601_ LQSSG 606_ FPEIL 611_ DANKQ 616_ PAEAV 621_ SATEP 626_ VTFNP 631_ QKEES 636_ DCLQS 641_ NEMVL 646_ QFLAF 651_ SRVAQ 656_ DCRGT 661_ SWPKT 666_ VYFTF 671_ QFYRF 676_ PPATT 681_ PRLQL 686_ VQLDE 691_ AGQPS 696_ SGALT 701_ HILVP 706_ VSRDG 711_ TFDAG 716_ SPGFQ 721_ LRYMV 726_ GPGFL 731_ KPGER 736_ RCFAR 741_ YLAVQ 746_ TLQID 751_ VWDGD 756_ SLLLI 761_ GSAAV 766_ QMKHL 771_ LRQGR 776_ PAVQA 781_ SHELE 786_ VVATE 791_ YEQDN 796_ MVVSG 801_ DMLGF 806_ GRVKP 811_ IGVHS 816_ VVKGR 821_ LHLTL 826_ ANVGH 831_ PCEQK 836_ VRGCS 841_ TLPPS 846_ RSRVI 851_ SNDGA 856_ SRFSG 861_ GSLLT 866_ TGSSR 871_ RKHVV 876_ QAQKL 881_ ADVDS 886_ ELAAM 891_ LLTHA 896_ RQGKG 901_ PQDVS 906_ RESDA 911_ TRRRK 916_ LERMR 921_ SVRLQ 926_ EAGGD 931_ LGRRG 936_ TSVLA 941_ QQSVR 946_ TQHLR 951_ DLQVI 956_ AAYRE 961_ RTKAE 966_ SIASL 971_ LSLAI 976_ TTEHT 981_ LHATL 986_ GVAEF 991_ FEFVL 996_ KNPHN 1001_ TQHTV 1006_ TVEID 1011_ NPELS 1016_ VIVDS 1021_ QEWRD 1026_ FKGAA 1031_ GLHTP 1036_ VEEDM 1041_ FHLRG 1046_ SLAPQ 1051_ LYLRP 1056_ HETAH 1061_ VPFKF 1066_ QSFSA 1071_ GQLAM 1076_ VQASP 1081_ GLSNE 1086_ KGMDA 1091_ VSPWK 1096_ SSAVP 1101_ TKHAK 1106_ VLFRA 1111_ SGGKP 1116_ IAVLC 1121_ LTVEL 1126_ QPHVV 1131_ DQVFR 1136_ FYHPE 1141_ LSFLK 1146_ KAIRL 1151_ PPWHT 1156_ FPGAP 1161_ VGMLG 1166_ EDPPV 1171_ HVRCS 1176_ DPNVI 1181_ CETQN 1186_ VGPGE 1191_ PRDIF 1196_ LKVAS 1201_ GPSPE 1206_ IKDFF 1211_ VIIYS 1216_ DRWLA 1221_ TPTQT 1226_ WQVYL 1231_ HSLQR 1236_ VDVSC 1241_ VAGQL 1246_ TRLSL 1251_ VLRGT 1256_ QTVRK 1261_ VRAFT 1266_ SHPQE 1271_ LKTDP 1276_ KGVFV 1281_ LPPRG 1286_ VQDLH 1291_ VGVRP 1296_ LRAGS 1301_ RFVHL 1306_ NLVDV 1311_ DCHQL 1316_ VASWL 1321_ VCLCC 1326_ RQPLI 1331_ SKAFE 1336_ IMLAA 1341_ GEGKG 1346_ VNKRI 1351_ TYTNP 1356_ YPSRR 1361_ TFHLH 1366_ SDHPE 1371_ LLRFR 1376_ EDSFQ 1381_ VGGGE 1386_ TYTIG 1391_ LQFAP 1396_ SQRVG 1401_ EEEIL 1406_ IYIND 1411_ HEDKN 1416_ EEAFC 1421_VKVIY
1: Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module (PubMed:19755384, PubMed:21565611). Does not seem to be strictly required for ciliogenesis (PubMed:21565611). Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity). In cooperation with INVS may down-regulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subcellular location of disheveled proteins. Stabilizes protein levels of JADE1 and promotes its translocation to the nucleus leading to cooperative inhibition of canonical Wnt signaling (PubMed:21498478, PubMed:22654112). Acts as a negative regulator of the hippo pathway by association with LATS1 and modifying LATS1-dependent phosphorylation and localization of WWTR1/TAZ (PubMed:21555462)