Lysine-specific demethylase 4A (EC 1.14.11.66) (EC 1.14.11.69) (JmjC domain-containing histone demethylation protein 3A) (Jumonji domain-containing protein 2A) ([histone H3]-trimethyl-L-lysine(36) demethylase 4A) ([histone H3]-trimethyl-L-lysine(9) demethylase 4A)
1_MASES 6_ ETLNP 11_ SARIM 16_ TFYPT 21_ MEEFR 26_ NFSRY 31_ IAYIE 36_ SQGAH 41_ RAGLA 46_ KVVPP 51_ KEWKP 56_ RASYD 61_ DIDDL 66_ VIPAP 71_ IQQLV 76_ TGQSG 81_ LFTQY 86_ NIQKK 91_ AMTVR 96_ EFRKI 101_ ANSDK 106_ YCTPR 111_ YSEFE 116_ ELERK 121_ YWKNL 126_ TFNPP 131_ IYGAD 136_ VNGTL 141_ YEKHV 146_ DEWNI 151_ GRLRT 156_ ILDLV 161_ EKESG 166_ ITIEG 171_ VNTPY 176_ LYFGM 181_ WKTSF 186_ AWHTE 191_ DMDLY 196_ SINYL 201_ HFGEP 206_ KSWYS 211_ VPPEH 216_ GKRLE 221_ RLAKG 226_ FFPGS 231_ AQSCE 236_ AFLRH 241_ KMTLI 246_ SPLML 251_ KKYGI 256_ PFDKV 261_ TQEAG 266_ EFMIT 271_ FPYGY 276_ HAGFN 281_ HGFNC 286_ AESTN 291_ FATRR 296_ WIEYG 301_ KQAVL 306_ CSCRK 311_ DMVKI 316_ SMDVF 321_ VRKFQ 326_ PERYK 331_ LWKAG 336_ KDNTV 341_ IDHTL 346_ PTPEA 351_ AEFLK 356_ ESELP 361_ PRAGN 366_ EEECP 371_ EEDME 376_ GVEDG 381_ EEGDL 386_ KTSLA 391_ KHRIG 396_ TKRHR 401_ VCLEI 406_ PQEVS 411_ QSELF 416_ PKEDL 421_ SSEQY 426_ EMTEC 431_ PAALA 436_ PVRPT 441_ HSSVR 446_ QVEDG 451_ LTFPD 456_ YSDST 461_ EVKFE 466_ ELKNV 471_ KLEEE 476_ DEEEE 481_ QAAAA 486_ LDLSV 491_ NPASV 496_ GGRLV 501_ FSGSK 506_ KKSSS 511_ SLGSG 516_ SSRDS 521_ ISSDS 526_ ETSEP 531_ LSCRA 536_ QGQTG 541_ VLTVH 546_ SYAKG 551_ DGRVT 556_ VGEPC 561_ TRKKG 566_ SAARS 571_ FSERE 576_ LAEVA 581_ DEYMF 586_ SLEEN 591_ KKSKG 596_ RRQPL 601_ SKLPR 606_ HHPLV 611_ LQECV 616_ SDDET 621_ SEQLT 626_ PEEEA 631_ EETEA 636_ WAKPL 641_ SQLWQ 646_ NRPPN 651_ FEAEK 656_ EFNET 661_ MAQQA 666_ PHCAV 671_ CMIFQ 676_ TYHQV 681_ EFGGF 686_ NQNCG 691_ NASDL 696_ APQKQ 701_ RTKPL 706_ IPEMC 711_ FTSTG 716_ CSTDI 721_ NLSTP 726_ YLEED 731_ GTSIL 736_ VSCKK 741_ CSVRV 746_ HASCY 751_ GVPPA 756_ KASED 761_ WMCSR 766_ CSANA 771_ LEEDC 776_ CLCSL 781_ RGGAL 786_ QRAND 791_ DRWVH 796_ VSCAV 801_ AILEA 806_ RFVNI 811_ AERSP 816_ VDVSK 821_ IPLPR 826_ FKLKC 831_ IFCKK 836_ RRKRT 841_ AGCCV 846_ QCSHG 851_ RCPTA 856_ FHVSC 861_ AQAAG 866_ VMMQP 871_ DDWPF 876_ VVFIT 881_ CFRHK 886_ IPNLE 891_ RAKGA 896_ LQSIT 901_ AGQKV 906_ ISKHK 911_ NGRFY 916_ QCEVV 921_ RLTTE 926_ TFYEV 931_ NFDDG 936_ SFSDN 941_ LYPED 946_ IVSQD 951_ CLQFG 956_ PPAEG 961_ EVVQV 966_ RWTDG 971_ QVYGA 976_ KFVAS 981_ HPIQM 986_ YQVEF 991_ EDGSQ 996_ LVVKR 1001_ DDVYT 1006_ LDEEL 1011_ PKRVK 1016_ SRLSV 1021_ ASDMR 1026_ FNEIF 1031_ TEKEV 1036_ KQEKK 1041_ RQRVI 1046_ NSRYR 1051_ EDYIE 1056_PALYR
1: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:26741168, PubMed:21768309). Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively
2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain