A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAM-TS 4) (ADAM-TS4) (ADAMTS-4) (EC 3.4.24.82) (ADMP-1) (Aggrecanase-1)
1_MSQTG 6_ SHPGR 11_ GLAGR 16_ WLWGA 21_ QPCLL 26_ LPIVP 31_ LSWLV 36_ WLLLL 41_ LLASL 46_ LPSAR 51_ LASPL 56_ PREEE 61_ IVFPE 66_ KLNGS 71_ VLPGS 76_ GAPAR 81_ LLCRL 86_ QAFGE 91_ TLLLE 96_ LEQDS 101_ GVQVE 106_ GLTVQ 111_ YLGQA 116_ PELLG 121_ GAEPG 126_ TYLTG 131_ TINGD 136_ PESVA 141_ SLHWD 146_ GGALL 151_ GVLQY 156_ RGAEL 161_ HLQPL 166_ EGGTP 171_ NSAGG 176_ PGAHI 181_ LRRKS 186_ PASGQ 191_ GPMCN 196_ VKAPL 201_ GSPSP 206_ RPRRA 211_ KRFAS 216_ LSRFV 221_ ETLVV 226_ ADDKM 231_ AAFHG 236_ AGLKR 241_ YLLTV 246_ MAAAA 251_ KAFKH 256_ PSIRN 261_ PVSLV 266_ VTRLV 271_ ILGSG 276_ EEGPQ 281_ VGPSA 286_ AQTLR 291_ SFCAW 296_ QRGLN 301_ TPEDS 306_ DPDHF 311_ DTAIL 316_ FTRQD 321_ LCGVS 326_ TCDTL 331_ GMADV 336_ GTVCD 341_ PARSC 346_ AIVED 351_ DGLQS 356_ AFTAA 361_ HELGH 366_ VFNML 371_ HDNSK 376_ PCISL 381_ NGPLS 386_ TSRHV 391_ MAPVM 396_ AHVDP 401_ EEPWS 406_ PCSAR 411_ FITDF 416_ LDNGY 421_ GHCLL 426_ DKPEA 431_ PLHLP 436_ VTFPG 441_ KDYDA 446_ DRQCQ 451_ LTFGP 456_ DSRHC 461_ PQLPP 466_ PCAAL 471_ WCSGH 476_ LNGHA 481_ MCQTK 486_ HSPWA 491_ DGTPC 496_ GPAQA 501_ CMGGR 506_ CLHMD 511_ QLQDF 516_ NIPQA 521_ GGWGP 526_ WGPWG 531_ DCSRT 536_ CGGGV 541_ QFSSR 546_ DCTRP 551_ VPRNG 556_ GKYCE 561_ GRRTR 566_ FRSCN 571_ TEDCP 576_ TGSAL 581_ TFREE 586_ QCAAY 591_ NHRTD 596_ LFKSF 601_ PGPMD 606_ WVPRY 611_ TGVAP 616_ QDQCK 621_ LTCQA 626_ QALGY 631_ YYVLE 636_ PRVVD 641_ GTPCS 646_ PDSSS 651_ VCVQG 656_ RCIHA 661_ GCDRI 666_ IGSKK 671_ KFDKC 676_ MVCGG 681_ DGSGC 686_ SKQSG 691_ SFRKF 696_ RYGYN 701_ NVVTI 706_ PAGAT 711_ HILVR 716_ QQGNP 721_ GHRSI 726_ YLALK 731_ LPDGS 736_ YALNG 741_ EYTLM 746_ PSPTD 751_ VVLPG 756_ AVSLR 761_ YSGAT 766_ AASET 771_ LSGHG 776_ PLAQP 781_ LTLQV 786_ LVAGN 791_ PQDTR 796_ LRYSF 801_ FVPRP 806_ TPSTP 811_ RPTPQ 816_ DWLHR 821_ RAQIL 826_ EILRR 831_RPWAG
1: Cleaves aggrecan, a cartilage proteoglycan, at the '392-Glu-|-Ala-393' site and may be involved in its turnover (PubMed:10356395, PubMed:10827174). Also cleaves COMP (PubMed:39672391). May play an important role in the destruction of aggrecan in arthritic diseases. Could be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease