CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3) (Leukocyte receptor cluster member 2)
1_MADKR 6_ KLQGE 11_ IDRCL 16_ KKVSE 21_ GVEQF 26_ EDIWQ 31_ KLHNA 36_ ANANQ 41_ KEKYE 46_ ADLKK 51_ EIKKL 56_ QRLRD 61_ QIKTW 66_ VASNE 71_ IKDKR 76_ QLIDN 81_ RKLIE 86_ TQMER 91_ FKVVE 96_ RETKT 101_ KAYSK 106_ EGLGL 111_ AQKVD 116_ PAQKE 121_ KEEVG 126_ QWLTN 131_ TIDTL 136_ NMQVD 141_ QFESE 146_ VESLS 151_ VQTRK 156_ KKGDK 161_ DKQDR 166_ IEGLK 171_ RHIEK 176_ HRYHV 181_ RMLET 186_ ILRML 191_ DNDSI 196_ LVDAI 201_ RKIKD 206_ DVEYY 211_ VDSSQ 216_ DPDFE 221_ ENEFL 226_ YDDLD 231_ LEDIP 236_ QALVA 241_ TSPPS 246_ HSHME 251_ DEIFN 256_ QSSST 261_ PTSTT 266_ SSSPI 271_ PPSPA 276_ NCTTE 281_ NSEDD 286_ KKRGR 291_ STDSE 296_ VSQSP 301_ AKNGS 306_ KPVHS 311_ NQHPQ 316_ SPAVP 321_ PTYPS 326_ GPPPA 331_ ASALS 336_ TTPGN 341_ NGVPA 346_ PAAPP 351_ SALGP 356_ KASPA 361_ PSHNS 366_ GTPAP 371_ YAQAV 376_ APPAP 381_ SGPST 386_ TQPRP 391_ PSVQP 396_ SGGGG 401_ GGSGG 406_ GGSSS 411_ SSNSS 416_ AGGGA 421_ GKQNG 426_ ATSYS 431_ SVVAD 436_ SPAEV 441_ ALSSS 446_ GGNNA 451_ SSQAL 456_ GPPSG 461_ PHNPP 466_ PSTSK 471_ EPSAA 476_ APTGA 481_ GGVAP 486_ GSGNN 491_ SGGPS 496_ LLVPL 501_ PVNPP 506_ SSPTP 511_ SFSDA 516_ KAAGA 521_ LLNGP 526_ PQFST 531_ APEIK 536_ APEPL 541_ SSLKS 546_ MAERA 551_ AISSG 556_ IEDPV 561_ PTLHL 566_ TERDI 571_ ILSST 576_ SAPPA 581_ SAQPP 586_ LQLSE 591_ VNIPL 596_ SLGVC 601_ PLGPV 606_ PLTKE 611_ QLYQQ 616_ AMEEA 621_ AWHHM 626_ PHPSD 631_ SERIR 636_ QYLPR 641_ NPCPT 646_ PPYHH 651_ QMPPP 656_ HSDTV 661_ EFYQR 666_ LSTET 671_ LFFIF 676_ YYLEG 681_ TKAQY 686_ LAAKA 691_ LKKQS 696_ WRFHT 701_ KYMMW 706_ FQRHE 711_ EPKTI 716_ TDEFE 721_ QGTYI 726_ YFDYE 731_ KWGQR 736_ KKEGF 741_ TFEYR 746_YLEDR
1: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity