Calcium-responsive transactivator (SS18-like protein 1) (SYT homolog 1)
1_MSVAF 6_ ASARP 11_ RGKGE 16_ VTQQT 21_ IQKML 26_ DENHH 31_ LIQCI 36_ LEYQS 41_ KGKTA 46_ ECTQY 51_ QQILH 56_ RNLVY 61_ LATIA 66_ DSNQN 71_ MQSLL 76_ PAPPT 81_ QNMNL 86_ GPGAL 91_ TQSGS 96_ SQGLH 101_ SQGSL 106_ SDAIS 111_ TGLPP 116_ SSLLQ 121_ GQIGN 126_ GPSHV 131_ SMQQT 136_ APNTL 141_ PTTSM 146_ SISGP 151_ GYSHA 156_ GPASQ 161_ GVPMQ 166_ GQGTI 171_ GNYVS 176_ RTNIN 181_ MQSNP 186_ VSMMQ 191_ QQAAT 196_ SHYSS 201_ AQGGS 206_ QHYQG 211_ QSSIA 216_ MMGQG 221_ SQGSS 226_ MMGQR 231_ PMAPY 236_ RPSQQ 241_ GSSQQ 246_ YLGQE 251_ EYYGE 256_ QYSHS 261_ QGAAE 266_ PMGQQ 271_ YYPDG 276_ HGDYA 281_ YQQSS 286_ YTEQS 291_ YDRSF 296_ EESTQ 301_ HYYEG 306_ GNSQY 311_ SQQQA 316_ GYQQG 321_ AAQQQ 326_ TYSQQ 331_ QYPSQ 336_ QSYPG 341_ QQQGY 346_ GSAQG 351_ APSQY 356_ PGYQQ 361_ GQGQQ 366_ YGSYR 371_ APQTA 376_ PSAQQ 381_ QRPYG 386_ YEQGQ 391_YGNYQ
1: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity)