Paired amphipathic helix protein Sin3b (Histone deacetylase complex subunit Sin3b) (Transcriptional corepressor Sin3b)
1_MAHAG 6_ GGSGG 11_ SGAGG 16_ PAGRG 21_ LSGAR 26_ WGRSG 31_ SAGHE 36_ KLPVH 41_ VEDAL 46_ TYLDQ 51_ VKIRF 56_ GSDPA 61_ TYNGF 66_ LEIMK 71_ EFKSQ 76_ SIDTP 81_ GVIRR 86_ VSQLF 91_ HEHPD 96_ LIVGF 101_ NAFLP 106_ LGYRI 111_ DIPKN 116_ GKLNI 121_ QSPLT 126_ SQENS 131_ HNHGD 136_ GAEDF 141_ KQQVP 146_ YKEDK 151_ PQVPL 156_ ESDSV 161_ EFNNA 166_ ISYVN 171_ KIKTR 176_ FLDHP 181_ EIYRS 186_ FLEIL 191_ HTYQK 196_ EQLNT 201_ RGRPF 206_ RGMSE 211_ EEVFT 216_ EVANL 221_ FRGQE 226_ DLLSE 231_ FGQFL 236_ PEAKR 241_ SLFTG 246_ NGPCE 251_ MHSVQ 256_ KNEHD 261_ KTPEH 266_ SRKRS 271_ RPSLL 276_ RPVSA 281_ PAKKK 286_ MKLRG 291_ TKDLS 296_ IAAVG 301_ KYGTL 306_ QEFSF 311_ FDKVR 316_ RVLKS 321_ QEVYE 326_ NFLRC 331_ IALFN 336_ QELVS 341_ GSELL 346_ QLVSP 351_ FLGKF 356_ PELFA 361_ QFKSF 366_ LGVKE 371_ LSFAP 376_ PMSDR 381_ SGDGI 386_ SREID 391_ YASCK 396_ RIGSS 401_ YRALP 406_ KTYQQ 411_ PKCSG 416_ RTAIC 421_ KELDH 426_ WTLLQ 431_ GSWTD 436_ DYCMS 441_ KFKNT 446_ CWIPG 451_ YSAGV 456_ LNDTW 461_ VSFPS 466_ WSEDS 471_ TFVSS 476_ KKTPY 481_ EEQLH 486_ RCEDE 491_ RFELD 496_ VVLET 501_ NLATI 506_ RVLES 511_ VQKKL 516_ SRMAP 521_ EDQEK 526_ FRLDD 531_ SLGGT 536_ SEVIQ 541_ RRAIY 546_ RIYGD 551_ KAPEI 556_ IESLK 561_ KNPVT 566_ AVPVV 571_ LKRLK 576_ AKEEE 581_ WREAQ 586_ QGFNK 591_ IWREQ 596_ YEKAY 601_ LKSLD 606_ HQAVN 611_ FKQND 616_ TKALR 621_ SKSLL 626_ NEIES 631_ VYDEH 636_ QEQHS 641_ EGRSA 646_ PSSEP 651_ HLIFV 656_ YEDRQ 661_ ILEDA 666_ AALIS 671_ YYVKR 676_ QPAIQ 681_ KEDQG 686_ TIHQL 691_ LHQFV 696_ PSLFF 701_ SQQLD 706_ LGASE 711_ ESADE 716_ DRDSP 721_ QGQTT 726_ DPSER 731_ KKPAP 736_ GPHSS 741_ PPEEK 746_ GAFGD 751_ APATE 756_ QPPLP 761_ PPAPH 766_ KPLDD 771_ VYSLF 776_ FANNN 781_ WYFFL 786_ RLHQT 791_ LCSRL 796_ LKIYR 801_ QAQKQ 806_ LLEYR 811_ TEKER 816_ EKLLC 821_ EGRRE 826_ KGSDP 831_ AMELR 836_ LKQPS 841_ EVELE 846_ EYYPA 851_ FLDMV 856_ RSLLE 861_ GSIDP 866_ TQYED 871_ TLREM 876_ FTIHA 881_ YVGFT 886_ MDKLV 891_ QNIAR 896_ QLHHL 901_ VSDDV 906_ CLKVV 911_ ELYLN 916_ EKKRG 921_ AAGGN 926_ LSSRC 931_ VRAAR 936_ ETSYQ 941_ WKAER 946_ CMADE 951_ NCFKV 956_ MFLQR 961_ KGQVI 966_ MTIEL 971_ LDTEE 976_ AQTED 981_ PVEVQ 986_ HLARY 991_ VEQYV 996_ GTEGA 1001_ SSSPT 1006_ EGFLL 1011_ KPVFL 1016_ QRNLK 1021_ KFRRR 1026_ WQSEQ 1031_ ARALR 1036_ GEARS 1041_ SWKRL 1046_ VGVES 1051_ ACDVD 1056_ CRFKL 1061_ STHKM 1066_ VFIVN 1071_ SEDYM 1076_ YRRGT 1081_ LCRAK 1086_ QVQPL 1091_ VLLRH 1096_ HQHFE 1101_ EWHSR 1106_ WLEDN 1111_ VTVEA 1116_ ASLVQ 1121_ DWLMG 1126_ EEDED 1131_ MVPCK 1136_ TLCET 1141_ VHVHG 1146_ LPVTR 1151_ YRVQY 1156_SRRPA
1: Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression. As part of the SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:37137925). SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (PubMed:21041482)