Calcium-transporting ATPase type 2C member 2 (ATPase 2C2) (EC 7.2.2.10) (Ca(2+)/Mn(2+)-ATPase 2C2) (Secretory pathway Ca(2+)-transporting ATPase type 2) (SPCA2)
1_MVEGR 6_ VSEFL 11_ KKLGF 16_ SGGGR 21_ QYQAL 26_ EKDEE 31_ EALID 36_ EQSEL 41_ KAIEK 46_ EKKVT 51_ ALPPK 56_ EACKC 61_ QKEDL 66_ ARAFC 71_ VDLHT 76_ GLSEF 81_ SVTQR 86_ RLAHG 91_ WNEFV 96_ ADNSE 101_ PVWKK 106_ YLDQF 111_ KNPLI 116_ LLLLG 121_ SALVS 126_ VLTKE 131_ YEDAV 136_ SIATA 141_ VLVVV 146_ TVAFI 151_ QEYRS 156_ EKSLE 161_ ELTKL 166_ VPPEC 171_ NCLRE 176_ GKLQH 181_ LLARE 186_ LVPGD 191_ VVSLS 196_ IGDRI 201_ PADIR 206_ LTEVT 211_ DLLVD 216_ ESSFT 221_ GEAEP 226_ CSKTD 231_ SPLTG 236_ GGDLT 241_ TLSNI 246_ VFMGT 251_ LVQYG 256_ RGQGV 261_ VIGTG 266_ ESSQF 271_ GEVFK 276_ MMQAE 281_ ETPKT 286_ PLQKS 291_ MDRLG 296_ KQLTL 301_ FSFGI 306_ IGLIM 311_ LIGWS 316_ QGKQL 321_ LSMFT 326_ IGVSL 331_ AVAAI 336_ PEGLP 341_ IVVMV 346_ TLVLG 351_ VLRMA 356_ KKRVI 361_ VKKLP 366_ IVETL 371_ GCCSV 376_ LCSDK 381_ TGTLT 386_ ANEMT 391_ VTQLV 396_ TSDGL 401_ RAEVS 406_ GVGYD 411_ GQGTV 416_ CLLPS 421_ KEVIK 426_ EFSNV 431_ SVGKL 436_ VEAGC 441_ VANNA 446_ VIRKN 451_ AVMGQ 456_ PTEGA 461_ LMALA 466_ MKMDL 471_ SDIKN 476_ SYIRK 481_ KEIPF 486_ SSEQK 491_ WMAVK 496_ CSLKT 501_ EDQED 506_ IYFMK 511_ GALEE 516_ VIRYC 521_ TMYNN 526_ GGIPL 531_ PLTPQ 536_ QRSFC 541_ LQEEK 546_ RMGSL 551_ GLRVL 556_ ALASG 561_ PELGR 566_ LTFLG 571_ LVGII 576_ DPPRV 581_ GVKEA 586_ VQVLS 591_ ESGVS 596_ VKMIT 601_ GDALE 606_ TALAI 611_ GRNIG 616_ LCNGK 621_ LQAMS 626_ GEEVD 631_ SVEKG 636_ ELADR 641_ VGKVS 646_ VFFRT 651_ SPKHK 656_ LKIIK 661_ ALQES 666_ GAIVA 671_ MTGDG 676_ VNDAV 681_ ALKSA 686_ DIGIA 691_ MGQTG 696_ TDVSK 701_ EAANM 706_ ILVDD 711_ DFSAI 716_ MNAVE 721_ EGKGI 726_ FYNIK 731_ NFVRF 736_ QLSTS 741_ ISALS 746_ LITLS 751_ TVFNL 756_ PSPLN 761_ AMQIL 766_ WINII 771_ MDGPP 776_ AQSLG 781_ VEPVD 786_ KDAFR 791_ QPPRS 796_ VRDTI 801_ LSRAL 806_ ILKIL 811_ MSAAI 816_ IISGT 821_ LFIFW 826_ KEMPE 831_ DRAST 836_ PRTTT 841_ MTFTC 846_ FVFFD 851_ LFNAL 856_ TCRSQ 861_ TKLIF 866_ EIGFL 871_ RNHMF 876_ LYSVL 881_ GSILG 886_ QLAVI 891_ YIPPL 896_ QRVFQ 901_ TENLG 906_ ALDLL 911_ FLTGL 916_ ASSVF 921_ ILSEL 926_ LKLCE 931_ KYCCS 936_ PKRVQ 941_MHPED
1: ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway (PubMed:15677451, PubMed:15831496, PubMed:16332677, PubMed:30923126). Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:15831496, PubMed:16332677). Induces Ca(2+) influx independently of its ATP-driven pump function. At the basolateral membrane of mammary epithelial cells, interacts with Ca(2+) channel ORAI1 and mediates Ca(2+) entry independently of the Ca(2+) content of endoplasmic reticulum or Golgi stores. May facilitate transepithelial transport of large quantities of Ca(2+) for milk secretion via activation of Ca(2+) influx channels at the plasma membrane and active Ca(2+) transport at the Golgi apparatus (PubMed:20887894, PubMed:23840669)