DnaJ homolog subfamily B member 6 (HHDJ1) (Heat shock protein J2) (HSJ-2) (MRJ) (MSJ-1)
1_MVDYY 6_ EVLGV 11_ QRHAS 16_ PEDIK 21_ KAYRK 26_ LALKW 31_ HPDKN 36_ PENKE 41_ EAERK 46_ FKQVA 51_ EAYEV 56_ LSDAK 61_ KRDIY 66_ DKYGK 71_ EGLNG 76_ GGGGG 81_ SHFDS 86_ PFEFG 91_ FTFRN 96_ PDDVF 101_ REFFG 106_ GRDPF 111_ SFDFF 116_ EDPFE 121_ DFFGN 126_ RRGPR 131_ GSRSR 136_ GTGSF 141_ FSAFS 146_ GFPSF 151_ GSGFS 156_ SFDTG 161_ FTSFG 166_ SLGHG 171_ GLTSF 176_ SSTSF 181_ GGSGM 186_ GNFKS 191_ ISTST 196_ KMVNG 201_ RKITT 206_ KRIVE 211_ NGQER 216_ VEVEE 221_ DGQLK 226_ SLTIN 231_ GVADD 236_ DALAE 241_ ERMRR 246_ GQNAL 251_ PAQPA 256_ GLRPP 261_ KPPRP 266_ ASLLR 271_ HAPHC 276_ LSEEE 281_ GEQDR 286_ PRAPG 291_ PWDPL 296_ ASAAG 301_ LKEGG 306_ KRKKQ 311_ KQREE 316_ SKKKK 321_STKGN
1: Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70 (PubMed:10954706, PubMed:28233300). Plays an indispensable role in the organization of KRT8/KRT18 filaments (PubMed:10954706). Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin (PubMed:11896048, PubMed:22366786). Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins (PubMed:20159555, PubMed:22366786). Also reduces cellular toxicity and caspase-3 activity (PubMed:11896048)
2: Isoform B but not isoform A inhibits huntingtin aggregation