Low-density lipoprotein receptor-related protein 5 (LRP-5) (Low-density lipoprotein receptor-related protein 7) (LRP-7)
1_MEAAP 6_ PGPPW 11_ PLLLL 16_ LLLLL 21_ ALCGC 26_ PAPAA 31_ ASPLL 36_ LFANR 41_ RDVRL 46_ VDAGG 51_ VKLES 56_ TIVVS 61_ GLEDA 66_ AAVDF 71_ QFSKG 76_ AVYWT 81_ DVSEE 86_ AIKQT 91_ YLNQT 96_ GAAVQ 101_ NVVIS 106_ GLVSP 111_ DGLAC 116_ DWVGK 121_ KLYWT 126_ DSETN 131_ RIEVA 136_ NLNGT 141_ SRKVL 146_ FWQDL 151_ DQPRA 156_ IALDP 161_ AHGYM 166_ YWTDW 171_ GETPR 176_ IERAG 181_ MDGST 186_ RKIIV 191_ DSDIY 196_ WPNGL 201_ TIDLE 206_ EQKLY 211_ WADAK 216_ LSFIH 221_ RANLD 226_ GSFRQ 231_ KVVEG 236_ SLTHP 241_ FALTL 246_ SGDTL 251_ YWTDW 256_ QTRSI 261_ HACNK 266_ RTGGK 271_ RKEIL 276_ SALYS 281_ PMDIQ 286_ VLSQE 291_ RQPFF 296_ HTRCE 301_ EDNGG 306_ CSHLC 311_ LLSPS 316_ EPFYT 321_ CACPT 326_ GVQLQ 331_ DNGRT 336_ CKAGA 341_ EEVLL 346_ LARRT 351_ DLRRI 356_ SLDTP 361_ DFTDI 366_ VLQVD 371_ DIRHA 376_ IAIDY 381_ DPLEG 386_ YVYWT 391_ DDEVR 396_ AIRRA 401_ YLDGS 406_ GAQTL 411_ VNTEI 416_ NDPDG 421_ IAVDW 426_ VARNL 431_ YWTDT 436_ GTDRI 441_ EVTRL 446_ NGTSR 451_ KILVS 456_ EDLDE 461_ PRAIA 466_ LHPVM 471_ GLMYW 476_ TDWGE 481_ NPKIE 486_ CANLD 491_ GQERR 496_ VLVNA 501_ SLGWP 506_ NGLAL 511_ DLQEG 516_ KLYWG 521_ DAKTD 526_ KIEVI 531_ NVDGT 536_ KRRTL 541_ LEDKL 546_ PHIFG 551_ FTLLG 556_ DFIYW 561_ TDWQR 566_ RSIER 571_ VHKVK 576_ ASRDV 581_ IIDQL 586_ PDLMG 591_ LKAVN 596_ VAKVV 601_ GTNPC 606_ ADRNG 611_ GCSHL 616_ CFFTP 621_ HATRC 626_ GCPIG 631_ LELLS 636_ DMKTC 641_ IVPEA 646_ FLVFT 651_ SRAAI 656_ HRISL 661_ ETNNN 666_ DVAIP 671_ LTGVK 676_ EASAL 681_ DFDVS 686_ NNHIY 691_ WTDVS 696_ LKTIS 701_ RAFMN 706_ GSSVE 711_ HVVEF 716_ GLDYP 721_ EGMAV 726_ DWMGK 731_ NLYWA 736_ DTGTN 741_ RIEVA 746_ RLDGQ 751_ FRQVL 756_ VWRDL 761_ DNPRS 766_ LALDP 771_ TKGYI 776_ YWTEW 781_ GGKPR 786_ IVRAF 791_ MDGTN 796_ CMTLV 801_ DKVGR 806_ ANDLT 811_ IDYAD 816_ QRLYW 821_ TDLDT 826_ NMIES 831_ SNMLG 836_ QERVV 841_ IADDL 846_ PHPFG 851_ LTQYS 856_ DYIYW 861_ TDWNL 866_ HSIER 871_ ADKTS 876_ GRNRT 881_ LIQGH 886_ LDFVM 891_ DILVF 896_ HSSRQ 901_ DGLND 906_ CMHNN 911_ GQCGQ 916_ LCLAI 921_ PGGHR 926_ CGCAS 931_ HYTLD 936_ PSSRN 941_ CSPPT 946_ TFLLF 951_ SQKSA 956_ ISRMI 961_ PDDQH 966_ SPDLI 971_ LPLHG 976_ LRNVK 981_ AIDYD 986_ PLDKF 991_ IYWVD 996_ GRQNI 1001_ KRAKD 1006_ DGTQP 1011_ FVLTS 1016_ LSQGQ 1021_ NPDRQ 1026_ PHDLS 1031_ IDIYS 1036_ RTLFW 1041_ TCEAT 1046_ NTINV 1051_ HRLSG 1056_ EAMGV 1061_ VLRGD 1066_ RDKPR 1071_ AIVVN 1076_ AERGY 1081_ LYFTN 1086_ MQDRA 1091_ AKIER 1096_ AALDG 1101_ TEREV 1106_ LFTTG 1111_ LIRPV 1116_ ALVVD 1121_ NTLGK 1126_ LFWVD 1131_ ADLKR 1136_ IESCD 1141_ LSGAN 1146_ RLTLE 1151_ DANIV 1156_ QPLGL 1161_ TILGK 1166_ HLYWI 1171_ DRQQQ 1176_ MIERV 1181_ EKTTG 1186_ DKRTR 1191_ IQGRV 1196_ AHLTG 1201_ IHAVE 1206_ EVSLE 1211_ EFSAH 1216_ PCARD 1221_ NGGCS 1226_ HICIA 1231_ KGDGT 1236_ PRCSC 1241_ PVHLV 1246_ LLQNL 1251_ LTCGE 1256_ PPTCS 1261_ PDQFA 1266_ CATGE 1271_ IDCIP 1276_ GAWRC 1281_ DGFPE 1286_ CDDQS 1291_ DEEGC 1296_ PVCSA 1301_ AQFPC 1306_ ARGQC 1311_ VDLRL 1316_ RCDGE 1321_ ADCQD 1326_ RSDEA 1331_ DCDAI 1336_ CLPNQ 1341_ FRCAS 1346_ GQCVL 1351_ IKQQC 1356_ DSFPD 1361_ CIDGS 1366_ DELMC 1371_ EITKP 1376_ PSDDS 1381_ PAHSS 1386_ AIGPV 1391_ IGIIL 1396_ SLFVM 1401_ GGVYF 1406_ VCQRV 1411_ VCQRY 1416_ AGANG 1421_ PFPHE 1426_ YVSGT 1431_ PHVPL 1436_ NFIAP 1441_ GGSQH 1446_ GPFTG 1451_ IACGK 1456_ SMMSS 1461_ VSLMG 1466_ GRGGV 1471_ PLYDR 1476_ NHVTG 1481_ ASSSS 1486_ SSSTK 1491_ ATLYP 1496_ PILNP 1501_ PPSPA 1506_ TDPSL 1511_ YNMDM 1516_ FYSSN 1521_ IPATA 1526_ RPYRP 1531_ YIIRG 1536_ MAPPT 1541_ TPCST 1546_ DVCDS 1551_ DYSAS 1556_ RWKAS 1561_ KYYLD 1566_ LNSDS 1571_ DPYPP 1576_ PPTPH 1581_ SQYLS 1586_ AEDSC 1591_ PPSPA 1596_ TERSY 1601_ FHLFP 1606_PPPSP
1: Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins (PubMed:11336703, PubMed:11448771, PubMed:11719191, PubMed:15778503, PubMed:15908424, PubMed:16252235). Activates the canonical Wnt signaling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration (PubMed:11336703, PubMed:11719191). In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation (By similarity). During bone development, regulates osteoblast proliferation and differentiation thus determining bone mass (PubMed:11719191). Mechanistically, the formation of the signaling complex between Wnt ligand, frizzled receptor and LRP5 coreceptor promotes the recruitment of AXIN1 to LRP5, stabilizing beta-catenin/CTNNB1 and activating TCF/LEF-mediated transcriptional programs (PubMed:11336703, PubMed:14731402, PubMed:24706814, PubMed:25920554). Acts as a coreceptor for non-Wnt proteins, such as norrin/NDP. Binding of norrin/NDP to frizzled 4/FZD4-LRP5 receptor complex triggers beta-catenin/CTNNB1-dependent signaling known to be required for retinal vascular development (PubMed:16252235, PubMed:27228167). Plays a role in controlling postnatal vascular regression in retina via macrophage-induced endothelial cell apoptosis (By similarity)