NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (EC 7.1.1.2) (Complex I-49kD) (CI-49kD) (NADH-ubiquinone oxidoreductase 49 kDa subunit)
1_MAALR 6_ ALCGF 11_ RGVAA 16_ QVLRP 21_ GAGVR 26_ LPIQP 31_ SRGVR 36_ QWQPD 41_ VEWAQ 46_ QFGGA 51_ VMYPS 56_ KETAH 61_ WKPPP 66_ WNDVD 71_ PPKDT 76_ IVKNI 81_ TLNFG 86_ PQHPA 91_ AHGVL 96_ RLVME 101_ LSGEM 106_ VRKCD 111_ PHIGL 116_ LHRGT 121_ EKLIE 126_ YKTYL 131_ QALPY 136_ FDRLD 141_ YVSMM 146_ CNEQA 151_ YSLAV 156_ EKLLN 161_ IRPPP 166_ RAQWI 171_ RVLFG 176_ EITRL 181_ LNHIM 186_ AVTTH 191_ ALDLG 196_ AMTPF 201_ FWLFE 206_ EREKM 211_ FEFYE 216_ RVSGA 221_ RMHAA 226_ YIRPG 231_ GVHQD 236_ LPLGL 241_ MDDIY 246_ QFSKN 251_ FSLRL 256_ DELEE 261_ LLTNN 266_ RIWRN 271_ RTIDI 276_ GVVTA 281_ EEALN 286_ YGFSG 291_ VMLRG 296_ SGIQW 301_ DLRKT 306_ QPYDV 311_ YDQVE 316_ FDVPV 321_ GSRGD 326_ CYDRY 331_ LCRVE 336_ EMRQS 341_ LRIIA 346_ QCLNK 351_ MPPGE 356_ IKVDD 361_ AKVSP 366_ PKRAE 371_ MKTSM 376_ ESLIH 381_ HFKLY 386_ TEGYQ 391_ VPPGA 396_ TYTAI 401_ EAPKG 406_ EFGVY 411_ LVSDG 416_ SSRPY 421_ RCKIK 426_ APGFA 431_ HLAGL 436_ DKMSK 441_ GHMLA 446_ DVVAI 451_ IGTQD 456_IVFGE
1: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:22036843, PubMed:28031252, PubMed:30922174). Essential for the catalytic activity of complex I (PubMed:22036843, PubMed:30922174). Essential for the assembly of complex I (By similarity). Redox-sensitive, critical component of the oxygen-sensing pathway in the pulmonary vasculature which plays a key role in acute pulmonary oxygen-sensing and hypoxic pulmonary vasoconstriction (PubMed:30922174). Plays an important role in carotid body sensing of hypoxia (By similarity). Essential for glia-like neural stem and progenitor cell proliferation, differentiation and subsequent oligodendrocyte or neuronal maturation (By similarity)