Protein NipSnap homolog 2 (NipSnap2) (Glioblastoma-amplified sequence)
1_MAARV 6_ LRARG 11_ AAWAG 16_ GLLQR 21_ AAPCS 26_ LLPRL 31_ RTWTS 36_ SSNRS 41_ REDSW 46_ LKSLF 51_ VRKVD 56_ PRKDA 61_ HSNLL 66_ AKKET 71_ SNLYK 76_ LQFHN 81_ VKPEC 86_ LEAYN 91_ KICQE 96_ VLPKI 101_ HEDKH 106_ YPCTL 111_ VGTWN 116_ TWYGE 121_ QDQAV 126_ HLWRY 131_ EGGYP 136_ ALTEV 141_ MNKLR 146_ ENKEF 151_ LEFRK 156_ ARSDM 161_ LLSRK 166_ NQLLL 171_ EFSFW 176_ NEPVP 181_ RSGPN 186_ IYELR 191_ SYQLR 196_ PGTMI 201_ EWGNY 206_ WARAI 211_ RFRQD 216_ GNEAV 221_ GGFFS 226_ QIGQL 231_ YMVHH 236_ LWAYR 241_ DLQTR 246_ EDIRN 251_ AAWHK 256_ HGWEE 261_ LVYYT 266_ VPLIQ 271_ EMESR 276_ IMIPL 281_KTSPL
1: Protein involved in mitophagy by facilitating recruitment of the autophagy machinery required for clearance of damaged mitochondria (PubMed:30982665). Accumulates on the mitochondria surface in response to mitochondrial depolarization and acts as a 'eat me' signal by recruiting proteins involved in selective autophagy, such as autophagy receptors (CALCOCO2/NDP52, NBR1, SQSTM1/p62, TAX1BP1 and WDFY3/ALFY) and ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2) (PubMed:30982665)