Cartilage intermediate layer protein 1 (CILP-1) (Cartilage intermediate-layer protein) [Cleaved into: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2]
1_MVGTK 6_ AWVFS 11_ FLVLE 16_ VTSVL 21_ GRQTM 26_ LTQSV 31_ RRVQP 36_ GKKNP 41_ SIFAK 46_ PADTL 51_ ESPGE 56_ WTTWF 61_ NIDYP 66_ GGKGD 71_ YERLD 76_ AIRFY 81_ YGDRV 86_ CARPL 91_ RLEAR 96_ TTDWT 101_ PAGST 106_ GQVVH 111_ GSPRE 116_ GFWCL 121_ NREQR 126_ PGQNC 131_ SNYTV 136_ RFLCP 141_ PGSLR 146_ RDTER 151_ IWSPW 156_ SPWSK 161_ CSAAC 166_ GQTGV 171_ QTRTR 176_ ICLAE 181_ MVSLC 186_ SEASE 191_ EGQHC 196_ MGQDC 201_ TACDL 206_ TCPMG 211_ QVNAD 216_ CDACM 221_ CQDFM 226_ LHGAV 231_ SLPGG 236_ APASG 241_ AAIYL 246_ LTKTP 251_ KLLTQ 256_ TDSDG 261_ RFRIP 266_ GLCPD 271_ GKSIL 276_ KITKV 281_ KFAPI 286_ VLTMP 291_ KTSLK 296_ AATIK 301_ AEFVR 306_ AETPY 311_ MVMNP 316_ ETKAR 321_ RAGQS 326_ VSLCC 331_ KATGK 336_ PRPDK 341_ YFWYH 346_ NDTLL 351_ DPSLY 356_ KHESK 361_ LVLRK 366_ LQQHQ 371_ AGEYF 376_ CKAQS 381_ DAGAV 386_ KSKVA 391_ QLIVI 396_ ASDET 401_ PCNPV 406_ PESYL 411_ IRLPH 416_ DCFQN 421_ ATNSF 426_ YYDVG 431_ RCPVK 436_ TCAGQ 441_ QDNGI 446_ RCRDA 451_ VQNCC 456_ GISKT 461_ EEREI 466_ QCSGY 471_ TLPTK 476_ VAKEC 481_ SCQRC 486_ TETRS 491_ IVRGR 496_ VSAAD 501_ NGEPM 506_ RFGHV 511_ YMGNS 516_ RVSMT 521_ GYKGT 526_ FTLHV 531_ PQDTE 536_ RLVLT 541_ FVDRL 546_ QKFVN 551_ TTKVL 556_ PFNKK 561_ GSAVF 566_ HEIKM 571_ LRRKK 576_ PITLE 581_ AMETN 586_ IIPLG 591_ EVVGE 596_ DPMAE 601_ LEIPS 606_ RSFYR 611_ QNGEP 616_ YIGKV 621_ KASVT 626_ FLDPR 631_ NISTA 636_ TAAQT 641_ DLNFI 646_ NDEGD 651_ TFPLR 656_ TYGMF 661_ SVDFR 666_ DEVTS 671_ EPLNA 676_ GKVKV 681_ HLDST 686_ QVKMP 691_ EHIST 696_ VKLWS 701_ LNPDT 706_ GLWEE 711_ EGDFK 716_ FENQR 721_ RNKRE 726_ DRTFL 731_ VGNLE 736_ IRERR 741_ LFNLD 746_ VPESR 751_ RCFVK 756_ VRAYR 761_ SERFL 766_ PSEQI 771_ QGVVI 776_ SVINL 781_ EPRTG 786_ FLSNP 791_ RAWGR 796_ FDSVI 801_ TGPNG 806_ ACVPA 811_ FCDDQ 816_ SPDAY 821_ SAYVL 826_ ASLAG 831_ EELQA 836_ VESSP 841_ KFNPN 846_ AIGVP 851_ QPYLN 856_ KLNYR 861_ RTDHE 866_ DPRVK 871_ KTAFQ 876_ ISMAK 881_ PRPNS 886_ AEESN 891_ GPIYA 896_ FENLR 901_ ACEEA 906_ PPSAA 911_ HFRFY 916_ QIEGD 921_ RYDYN 926_ TVPFN 931_ EDDPM 936_ SWTED 941_ YLAWW 946_ PKPME 951_ FRACY 956_ IKVKI 961_ VGPLE 966_ VNVRS 971_ RNMGG 976_ THRQT 981_ VGKLY 986_ GIRDV 991_ RSTRD 996_ RDQPN 1001_ VSAAC 1006_ LEFKC 1011_ SGMLY 1016_ DQDRV 1021_ DRTLV 1026_ KVIPQ 1031_ GSCRR 1036_ ASVNP 1041_ MLHEY 1046_ LVNHL 1051_ PLAVN 1056_ NDTSE 1061_ YTMLA 1066_ PLDPL 1071_ GHNYG 1076_ IYTVT 1081_ DQDPR 1086_ TAKEI 1091_ ALGRC 1096_ FDGTS 1101_ DGSSR 1106_ IMKSN 1111_ VGVAL 1116_ TFNCV 1121_ ERQVG 1126_ RQSAF 1131_ QYLQS 1136_ TPAQS 1141_ PAAGT 1146_ VQGRV 1151_ PSRRQ 1156_ QRASR 1161_ GGQRQ 1166_ GGVVA 1171_ SLRFP 1176_RVAQQ
1: Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage