Programmed cell death protein 6 (Apoptosis-linked gene 2 protein homolog) (ALG-2)
1_MAAYS 6_ YRPGP 11_ GAGPG 16_ PAAGA 21_ ALPDQ 26_ SFLWN 31_ VFQRV 36_ DKDRS 41_ GVISD 46_ TELQQ 51_ ALSNG 56_ TWTPF 61_ NPVTV 66_ RSIIS 71_ MFDRE 76_ NKAGV 81_ NFSEF 86_ TGVWK 91_ YITDW 96_ QNVFR 101_ TYDRD 106_ NSGMI 111_ DKNEL 116_ KQALS 121_ GFGYR 126_ LSDQF 131_ HDILI 136_ RKFDR 141_ QGRGQ 146_ IAFDD 151_ FIQGC 156_ IVLQR 161_ LTDIF 166_ RRYDT 171_ DQDGW 176_ IQVSY 181_ EQYLS 186_MVFSI
1: Calcium sensor that plays a key role in processes such as endoplasmic reticulum (ER)-Golgi vesicular transport, endosomal biogenesis or membrane repair. Acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium: calcium-binding triggers exposure of apolar surface, promoting interaction with different sets of proteins thanks to 3 different hydrophobic pockets, leading to translocation to membranes (PubMed:20691033, PubMed:25667979). Involved in ER-Golgi transport by promoting the association between PDCD6IP and TSG101, thereby bridging together the ESCRT-III and ESCRT-I complexes (PubMed:19520058). Together with PEF1, acts as a calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in ER-Golgi transport by regulating the size of COPII coats (PubMed:27716508). In response to cytosolic calcium increase, the heterodimer formed with PEF1 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification (PubMed:27716508). Involved in the regulation of the distribution and function of MCOLN1 in the endosomal pathway (PubMed:19864416). Promotes localization and polymerization of TFG at endoplasmic reticulum exit site (PubMed:27813252). Required for T-cell receptor-, Fas-, and glucocorticoid-induced apoptosis (By similarity). May mediate Ca(2+)-regulated signals along the death pathway: interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity (PubMed:16132846). Its role in apoptosis may however be indirect, as suggested by knockout experiments (By similarity). May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphorylation of the Akt signaling pathway (PubMed:21893193). In case of infection by HIV-1 virus, indirectly inhibits HIV-1 production by affecting viral Gag expression and distribution (PubMed:27784779)
2: Has a lower Ca(2+) affinity than isoform 1 (By similarity)