Arachidonate 12-lipoxygenase, 12R-type (12R-LOX) (12R-lipoxygenase) (EC 1.13.11.-) (Epidermis-type lipoxygenase 12)
1_MATYK 6_ VRVAT 11_ GTDLL 16_ SGTRD 21_ SISLT 26_ IVGTQ 31_ GESHK 36_ QLLNH 41_ FGRDF 46_ ATGAV 51_ GQYTV 56_ QCPQD 61_ LGELI 66_ IIRLH 71_ KERYA 76_ FFPKD 81_ PWYCN 86_ YVQIC 91_ APNGR 96_ IYHFP 101_ AYQWM 106_ DGYET 111_ LALRE 116_ ATGKT 121_ TADDS 126_ LPVLL 131_ EHRKE 136_ EIRAK 141_ QDFYH 146_ WRVFL 151_ PGLPS 156_ YVHIP 161_ SYRPP 166_ VRRHR 171_ NPNRP 176_ EWNGY 181_ IPGFP 186_ ILINF 191_ KATKF 196_ LNLNL 201_ RYSFL 206_ KTASF 211_ FVRLG 216_ PMALA 221_ FKVRG 226_ LLDCK 231_ HSWKR 236_ LKDIR 241_ KIFPG 246_ KKSVV 251_ SEYVA 256_ EHWAE 261_ DTFFG 266_ YQYLN 271_ GVNPG 276_ LIRRC 281_ TRIPD 286_ KFPVT 291_ DDMVA 296_ PFLGE 301_ GTCLQ 306_ AELEK 311_ GNIYL 316_ ADYRI 321_ MEGIP 326_ TVELS 331_ GRKQH 336_ HCAPL 341_ CLLHF 346_ GPEGK 351_ MMPIA 356_ IQLSQ 361_ TPGPD 366_ CPIFL 371_ PSDSE 376_ WDWLL 381_ AKTWV 386_ RYAEF 391_ YSHEA 396_ IAHLL 401_ ETHLI 406_ AEAFC 411_ LALLR 416_ NLPMC 421_ HPLYK 426_ LLIPH 431_ TRYTV 436_ QINSI 441_ GRAVL 446_ LNEGG 451_ LSAKG 456_ MSLGV 461_ EGFAG 466_ VMVRA 471_ LSELT 476_ YDSLY 481_ LPNDF 486_ VERGV 491_ QDLPG 496_ YYYRD 501_ DSLAV 506_ WNALE 511_ KYVTE 516_ IITYY 521_ YPSDA 526_ AVEGD 531_ PELQS 536_ WVQEI 541_ FKECL 546_ LGRES 551_ SGFPR 556_ CLRTV 561_ PELIR 566_ YVTIV 571_ IYTCS 576_ AKHAA 581_ VNTGQ 586_ MEFTA 591_ WMPNF 596_ PASMR 601_ NPPIQ 606_ TKGLT 611_ TLETF 616_ MDTLP 621_ DVKTT 626_ CITLL 631_ VLWTL 636_ SREPD 641_ DRRPL 646_ GHFPD 651_ IHFVE 656_ EAPRR 661_ SIEAF 666_ RQRLN 671_ QISHD 676_ IRQRN 681_ KCLPI 686_ PYYYL 691_ DPVLI 696_ENSIS
1: Catalyzes the regio and stereo-specific incorporation of a single molecule of dioxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species (PubMed:21558561, PubMed:9618483, PubMed:9837935). In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins (PubMed:21558561). Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss (PubMed:21558561). May also play a role in the regulation of the expression of airway mucins (PubMed:22441738)