Inactive peptidyl-prolyl cis-trans isomerase FKBP6 (Inactive PPIase FKBP6) (36 kDa FK506-binding protein) (36 kDa FKBP) (FKBP-36) (FK506-binding protein 6) (FKBP-6) (Immunophilin FKBP36)
1_MGGSA 6_ LNQGV 11_ LEGDD 16_ APGQS 21_ LYERL 26_ SQRML 31_ DISGD 36_ RGVLK 41_ DVIRE 46_ GAGDL 51_ VAPDA 56_ SVLVK 61_ YSGYL 66_ EHMDR 71_ PFDSN 76_ YFRKT 81_ PRLMK 86_ LGEDI 91_ TLWGM 96_ ELGLL 101_ SMRRG 106_ ELARF 111_ LFKPN 116_ YAYGT 121_ LGCPP 126_ LIPPN 131_ TTVLF 136_ EIELL 141_ DFLDC 146_ AESDK 151_ FCALS 156_ AEQQD 161_ QFPLQ 166_ KVLKV 171_ AATER 176_ EFGNY 181_ LFRQN 186_ RFYDA 191_ KVRYK 196_ RALLL 201_ LRRRS 206_ APPEE 211_ QHLVE 216_ AAKLP 221_ VLLNL 226_ SFTYL 231_ KLDRP 236_ TIALC 241_ YGEQA 246_ LIIDQ 251_ KNAKA 256_ LFRCG 261_ QACLL 266_ LTEYQ 271_ KARDF 276_ LVRAQ 281_ KEQPF 286_ NHDIN 291_ NELKK 296_ LASCY 301_ RDYVD 306_ KEKEM 311_ WHRMF 316_ APCGD 321_GSTAG
1: Has an essential role in spermatogenesis (PubMed:36150389). It is required to repress transposable elements and prevent their mobilization, which is essential for the germline integrity (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity). Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis (By similarity). May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes (By similarity)