V-type proton ATPase subunit G 1 (V-ATPase subunit G 1) (V-ATPase 13 kDa subunit 1) (Vacuolar proton pump subunit G 1) (Vacuolar proton pump subunit M16)
1_MASQS 6_ QGIQQ 11_ LLQAE 16_ KRAAE 21_ KVSEA 26_ RKRKN 31_ RRLKQ 36_ AKEEA 41_ QAEIE 46_ QYRLQ 51_ REKEF 56_ KAKEA 61_ AALGS 66_ RGSCS 71_ TEVEK 76_ ETQEK 81_ MTILQ 86_ TYFRQ 91_ NRDEV 96_ LDNLL 101_ AFVCD 106_ IRPEI 111_HENYR
1: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32001091, PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32001091). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633)