Vacuolar protein sorting-associated protein 4B (EC 3.6.4.6) (Cell migration-inducing gene 1 protein) (Suppressor of K(+) transport growth defect 1) (Protein SKD1)
1_MSSTS 6_ PNLQK 11_ AIDLA 16_ SKAAQ 21_ EDKAG 26_ NYEEA 31_ LQLYQ 36_ HAVQY 41_ FLHVV 46_ KYEAQ 51_ GDKAK 56_ QSIRA 61_ KCTEY 66_ LDRAE 71_ KLKEY 76_ LKNKE 81_ KKAQK 86_ PVKEG 91_ QPSPA 96_ DEKGN 101_ DSDGE 106_ GESDD 111_ PEKKK 116_ LQNQL 121_ QGAIV 126_ IERPN 131_ VKWSD 136_ VAGLE 141_ GAKEA 146_ LKEAV 151_ ILPIK 156_ FPHLF 161_ TGKRT 166_ PWRGI 171_ LLFGP 176_ PGTGK 181_ SYLAK 186_ AVATE 191_ ANNST 196_ FFSIS 201_ SSDLV 206_ SKWLG 211_ ESEKL 216_ VKNLF 221_ QLARE 226_ NKPSI 231_ IFIDE 236_ IDSLC 241_ GSRSE 246_ NESEA 251_ ARRIK 256_ TEFLV 261_ QMQGV 266_ GVDND 271_ GILVL 276_ GATNI 281_ PWVLD 286_ SAIRR 291_ RFEKR 296_ IYIPL 301_ PEPHA 306_ RAAMF 311_ KLHLG 316_ TTQNS 321_ LTEAD 326_ FRELG 331_ RKTDG 336_ YSGAD 341_ ISIIV 346_ RDALM 351_ QPVRK 356_ VQSAT 361_ HFKKV 366_ RGPSR 371_ ADPNH 376_ LVDDL 381_ LTPCS 386_ PGDPG 391_ AIEMT 396_ WMDVP 401_ GDKLL 406_ EPVVS 411_ MSDML 416_ RSLSN 421_ TKPTV 426_ NEHDL 431_ LKLKK 436_FTEDF
1: Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their ATP-dependent disassembly, possibly in combination with membrane fission (PubMed:18687924). Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413)
2: (Microbial infection) In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses)