Ectonucleoside triphosphate diphosphohydrolase 6 (NTPDase 6) (EC 3.6.1.6) (CD39 antigen-like 2)
1_MKKGI 6_ RYETS 11_ RKTSY 16_ IFQQP 21_ QHGPW 26_ QTRMR 31_ KISNH 36_ GSLRV 41_ AKVAY 46_ PLGLC 51_ VGVFI 56_ YVAYI 61_ KWHRA 66_ TATQA 71_ FFSIT 76_ RAAPG 81_ ARWGQ 86_ QAHSP 91_ LGTAA 96_ DGHEV 101_ FYGIM 106_ FDAGS 111_ TGTRV 116_ HVFQF 121_ TRPPR 126_ ETPTL 131_ THETF 136_ KALKP 141_ GLSAY 146_ ADDVE 151_ KSAQG 156_ IRELL 161_ DVAKQ 166_ DIPFD 171_ FWKAT 176_ PLVLK 181_ ATAGL 186_ RLLPG 191_ EKAQK 196_ LLQKV 201_ KKVFK 206_ ASPFL 211_ VGDDC 216_ VSIMN 221_ GTDEG 226_ VSAWI 231_ TINFL 236_ TGSLK 241_ TPGGS 246_ SVGML 251_ DLGGG 256_ STQIA 261_ FLPRV 266_ EGTLQ 271_ ASPPG 276_ YLTAL 281_ RMFNR 286_ TYKLY 291_ SYSYL 296_ GLGLM 301_ SARLA 306_ ILGGV 311_ EGQPA 316_ KDGKE 321_ LVSPC 326_ LSPSF 331_ KGEWE 336_ HAEVT 341_ YRVSG 346_ QKAAA 351_ SLHEL 356_ CAARV 361_ SEVLQ 366_ NRVHR 371_ TEEVK 376_ HVDFY 381_ AFSYY 386_ YDLAA 391_ GVGLI 396_ DAEKG 401_ GSLVV 406_ GDFEI 411_ AAKYV 416_ CRTLE 421_ TQPQS 426_ SPFSC 431_ MDLTY 436_ VSLLL 441_ QEFGF 446_ PRSKV 451_ LKLTR 456_ KIDNV 461_ ETSWA 466_ LGAIF 471_ HYIDS 476_LNRQK
1: Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner. Has a strong preference for nucleoside diphosphates, preferentially hydrolyzes GDP, IDP, and UDP, with slower hydrolysis of CDP, ITP, GTP, CTP, ADP, and UTP and virtually no hydrolysis of ATP (PubMed:10948193, PubMed:11041856, PubMed:14529283). The membrane bound form might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides (PubMed:10948193, PubMed:11041856, PubMed:14529283)