Nucleoside diphosphate phosphatase ENTPD5 (EC 3.6.1.6) (CD39 antigen-like 4) (ER-UDPase) (Ectonucleoside triphosphate diphosphohydrolase 5) (NTPDase 5) (Guanosine-diphosphatase ENTPD5) (GDPase ENTPD5) (Inosine diphosphate phosphatase ENTPD5) (Nucleoside diphosphatase) (Uridine-diphosphatase ENTPD5) (UDPase ENTPD5)
1_MATSW 6_ GTVFF 11_ MLVVS 16_ CVCSA 21_ VSHRN 26_ QQTWF 31_ EGIFL 36_ SSMCP 41_ INVSA 46_ STLYG 51_ IMFDA 56_ GSTGT 61_ RIHVY 66_ TFVQK 71_ MPGQL 76_ PILEG 81_ EVFDS 86_ VKPGL 91_ SAFVD 96_ QPKQG 101_ AETVQ 106_ GLLEV 111_ AKDSI 116_ PRSHW 121_ KKTPV 126_ VLKAT 131_ AGLRL 136_ LPEHK 141_ AKALL 146_ FEVKE 151_ IFRKS 156_ PFLVP 161_ KGSVS 166_ IMDGS 171_ DEGIL 176_ AWVTV 181_ NFLTG 186_ QLHGH 191_ RQETV 196_ GTLDL 201_ GGAST 206_ QITFL 211_ PQFEK 216_ TLEQT 221_ PRGYL 226_ TSFEM 231_ FNSTY 236_ KLYTH 241_ SYLGF 246_ GLKAA 251_ RLATL 256_ GALET 261_ EGTDG 266_ HTFRS 271_ ACLPR 276_ WLEAE 281_ WIFGG 286_ VKYQY 291_ GGNQE 296_ GEVGF 301_ EPCYA 306_ EVLRV 311_ VRGKL 316_ HQPEE 321_ VQRGS 326_ FYAFS 331_ YYYDR 336_ AVDTD 341_ MIDYE 346_ KGGIL 351_ KVEDF 356_ ERKAR 361_ EVCDN 366_ LENFT 371_ SGSPF 376_ LCMDL 381_ SYITA 386_ LLKDG 391_ FGFAD 396_ STVLQ 401_ LTKKV 406_ NNIET 411_ GWALG 416_ ATFHL 421_LQSLG
1: Hydrolyzes nucleoside diphosphates with a preference for GDP, IDP and UDP compared to ADP and CDP (PubMed:10400613, PubMed:15698960). In the lumen of the endoplasmic reticulum, hydrolyzes UDP that acts as an end-product feedback inhibitor of the UDP-Glc:glycoprotein glucosyltransferases. UMP can be transported back by an UDP-sugar antiporter to the cytosol where it is consumed to regenerate UDP-glucose. Therefore, it positively regulates protein reglucosylation by clearing UDP from the ER lumen and by promoting the regeneration of UDP-glucose. Protein reglucosylation is essential to proper glycoprotein folding and quality control in the ER (By similarity)