Pituitary homeobox 3 (Homeobox protein PITX3) (Paired-like homeodomain transcription factor 3)
1_MEFGL 6_ LSEAE 11_ ARSPA 16_ LSLSD 21_ AGTPH 26_ PQLPE 31_ HGCKG 36_ QEHSD 41_ SEKAS 46_ ASLPG 51_ GSPED 56_ GSLKK 61_ KQRRQ 66_ RTHFT 71_ SQQLQ 76_ ELEAT 81_ FQRNR 86_ YPDMS 91_ TREEI 96_ AVWTN 101_ LTEAR 106_ VRVWF 111_ KNRRA 116_ KWRKR 121_ ERSQQ 126_ AELCK 131_ GSFAA 136_ PLGGL 141_ VPPYE 146_ EVYPG 151_ YSYGN 156_ WPPKA 161_ LAPPL 166_ AAKTF 171_ PFAFN 176_ SVNVG 181_ PLASQ 186_ PVFSP 191_ PSSIA 196_ ASMVP 201_ SAAAA 206_ PGTVP 211_ GPGAL 216_ QGLGG 221_ GPPGL 226_ APAAV 231_ SSGAV 236_ SCPYA 241_ SAAAA 246_ AAAAA 251_ SSPYV 256_ YRDPC 261_ NSSLA 266_ SLRLK 271_ AKQHA 276_ SFSYP 281_ AVHGP 286_ PPAAN 291_ LSPCQ 296_YAVER
1: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle (By similarity)