Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14)
1_MASSE 6_ QAEQP 11_ SQPSS 16_ TPGSE 21_ NVLPR 26_ EPLIA 31_ TAVKF 36_ LQNSR 41_ VRQSP 46_ LATRR 51_ AFLKK 56_ KGLTD 61_ EEIDM 66_ AFQQS 71_ GTAAD 76_ EPSSL 81_ GPATQ 86_ VVPVQ 91_ PPHLI 96_ SQPYS 101_ PAGSR 106_ WRDYG 111_ ALAII 116_ MAGIA 121_ FGFHQ 126_ LYKKY 131_ LLPLI 136_ LGGRE 141_ DRKQL 146_ ERMEA 151_ GLSEL 156_ SGSVA 161_ QTVTQ 166_ LQTTL 171_ ASVQE 176_ LLIQQ 181_ QQKIQ 186_ ELAHE 191_ LAAAK 196_ ATTST 201_ NWILE 206_ SQNIN 211_ ELKSE 216_ INSLK 221_ GLLLN 226_ RRQFP 231_ PSPSA 236_ PKIPS 241_ WQIPV 246_ KSPSP 251_ SSPAA 256_ VNHHS 261_ SSDIS 266_ PVSNE 271_ STSSS 276_ PGKEG 281_ HSPEG 286_ STVTY 291_ HLLGP 296_ QEEGE 301_ GVVDV 306_ KGQVR 311_ MEVQG 316_ EEEKR 321_ EDKED 326_ EEDEE 331_ DDDVS 336_ HVDEE 341_ DCLGV 346_ QREDR 351_ RGGDG 356_ QINEQ 361_ VEKLR 366_ RPEGA 371_SNESE
1: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (PubMed:24235149, PubMed:28765278, PubMed:9653144). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed:24235149, PubMed:28765278). Plays a key role for peroxisome movement through a direct interaction with tubulin (PubMed:21525035)