Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97)
1_MAKRE 6_ DSPGP 11_ EVQPM 16_ DKQFL 21_ VCSIC 26_ LDRYQ 31_ CPKVL 36_ PCLHT 41_ FCERC 46_ LQNYI 51_ PAQSL 56_ TLSCP 61_ VCRQT 66_ SILPE 71_ QGVSA 76_ LQNNF 81_ FISSL 86_ MEAMQ 91_ QAPDG 96_ AHDPE 101_ DPHPL 106_ SVVAG 111_ RPLSC 116_ PNHEG 121_ KTMEF 126_ YCEAC 131_ ETAMC 136_ GECRA 141_ GEHRE 146_ HGTVL 151_ LRDVV 156_ EQHKA 161_ ALQRQ 166_ LEAVR 171_ GRLPQ 176_ LSAAI 181_ ALVGG 186_ ISQQL 191_ QERKA 196_ EALAQ 201_ ISAAF 206_ EDLEQ 211_ ALQQR 216_ KQALV 221_ SDLET 226_ ICGAK 231_ QKVLQ 236_ SQLDT 241_ LRQGQ 246_ EHIGS 251_ SCSFA 256_ EQALR 261_ LGSAP 266_ EVLLV 271_ RKHMR 276_ ERLAA 281_ LAAQA 286_ FPERP 291_ HENAQ 296_ LELVL 301_ EVDGL 306_ RRSVL 311_ NLGAL 316_ LTTSA 321_ TAHET 326_ VATGE 331_ GLRQA 336_ LVGQP 341_ ASLTV 346_ TTKDK 351_ DGRLV 356_ RTGSA 361_ ELRAE 366_ ITGPD 371_ GTRLP 376_ VPVVD 381_ HKNGT 386_ YELVY 391_ TARTE 396_ GELLL 401_ SVLLY 406_ GQPVR 411_ GSPFR 416_ VRALR 421_ PGDLP 426_ PSPDD 431_ VKRRV 436_ KSPGG 441_ PGSHV 446_ RQKAV 451_ RRPSS 456_ MYSTG 461_ GKRKD 466_ NPIED 471_ ELVFR 476_ VGSRG 481_ REKGE 486_ FTNLQ 491_ GVSAA 496_ SSGRI 501_ VVADS 506_ NNQCI 511_ QVFSN 516_ EGQFK 521_ FRFGV 526_ RGRSP 531_ GQLQR 536_ PTGVA 541_ VDTNG 546_ DIIVA 551_ DYDNR 556_ WVSIF 561_ SPEGK 566_ FKTKI 571_ GAGRL 576_ MGPKG 581_ VAVDR 586_ NGHII 591_ VVDNK 596_ SCCVF 601_ TFQPN 606_ GKLVG 611_ RFGGR 616_ GATDR 621_ HFAGP 626_ HFVAV 631_ NNKNE 636_ IVVTD 641_ FHNHS 646_ VKVYS 651_ ADGEF 656_ LFKFG 661_ SHGEG 666_ NGQFN 671_ APTGV 676_ AVDSN 681_ GNIIV 686_ ADWGN 691_ SRIQV 696_ FDSSG 701_ SFLSY 706_ INTSA 711_ EPLYG 716_ PQGLA 721_ LTSDG 726_ HVVVA 731_ DAGNH 736_CFKAY
1: E3 ubiquitin ligase that plays essential roles in neuronal functions such as regulation of neuronal plasticity, learning, and memory (By similarity). In addition to its neuronal functions, participates in other biological processes such as innate immunity or cell cycle regulation. Component of the cytoskeleton-associated recycling or transport complex in neurons, polyubiquitinates gamma-actin, thus regulating neuronal plasticity, learning, and memory (By similarity). Ubiquitinates postsynaptic scaffold GKAP, a neuronal substrate involved in synaptic remodeling and thereby modulates dendritic spine morphology (By similarity). Positively regulates motility of microtubule-dependent motor protein KIF21B (By similarity). Induces growth arrest via its RING-dependent E3 ligase activity and ubiquinates CDKN1A (PubMed:24393003). Positively regulates TLR3-mediated signaling by mediating 'Lys-63'-linked polyubiquitination of TLR3 (PubMed:32878999). In turn, promotes the recognition and sorting of polyubiquitinated TLR3 by the ESCRT complexes (PubMed:32878999)