Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1)
1_MEPGR 6_ GGTET 11_ VGKFE 16_ FSRKD 21_ LIGHG 26_ AFAVV 31_ FKGRH 36_ REKHD 41_ LEVAV 46_ KCINK 51_ KNLAK 56_ SQTLL 61_ GKEIK 66_ ILKEL 71_ KHENI 76_ VALYD 81_ FQEMA 86_ NSVYL 91_ VMEYC 96_ NGGDL 101_ ADYLH 106_ AMRTL 111_ SEDTI 116_ RLFLQ 121_ QIAGA 126_ MRLLH 131_ SKGII 136_ HRDLK 141_ PQNIL 146_ LSNPA 151_ GRRAN 156_ PNSIR 161_ VKIAD 166_ FGFAR 171_ YLQSN 176_ MMAAT 181_ LCGSP 186_ MYMAP 191_ EVIMS 196_ QHYDG 201_ KADLW 206_ SIGTI 211_ VYQCL 216_ TGKAP 221_ FQASS 226_ PQDLR 231_ LFYEK 236_ NKTLV 241_ PTIPR 246_ ETSAP 251_ LRQLL 256_ LALLQ 261_ RNHKD 266_ RMDFD 271_ EFFHH 276_ PFLDA 281_ SPSVR 286_ KSPPV 291_ PVPSY 296_ PSSGS 301_ GSSSS 306_ SSSTS 311_ HLASP 316_ PSLGE 321_ MQQLQ 326_ KTLAS 331_ PADTA 336_ GFLHS 341_ SRDSG 346_ GSKDS 351_ SCDTD 356_ DFVMV 361_ PAQFP 366_ GDLVA 371_ EAPSA 376_ KPPPD 381_ SLMCS 386_ GSSLV 391_ ASAGL 396_ ESHGR 401_ TPSPS 406_ PPCSS 411_ SPSPS 416_ GRAGP 421_ FSSSR 426_ CGASV 431_ PIPVP 436_ TQVQN 441_ YQRIE 446_ RNLQS 451_ PTQFQ 456_ TPRSS 461_ AIRRS 466_ GSTSP 471_ LGFAR 476_ ASPSP 481_ PAHAE 486_ HGGVL 491_ ARKMS 496_ LGGGR 501_ PYTPS 506_ PQVGT 511_ IPERP 516_ GWSGT 521_ PSPQG 526_ AEMRG 531_ GRSPR 536_ PGSSA 541_ PEHSP 546_ RTSGL 551_ GCRLH 556_ SAPNL 561_ SDLHV 566_ VRPKL 571_ PKPPT 576_ DPLGA 581_ VFSPP 586_ QASPP 591_ QPSHG 596_ LQSCR 601_ NLRGS 606_ PKLPD 611_ FLQRN 616_ PLPPI 621_ LGSPT 626_ KAVPS 631_ FDFPK 636_ TPSSQ 641_ NLLAL 646_ LARQG 651_ VVMTP 656_ PRNRT 661_ LPDLS 666_ EVGPF 671_ HGQPL 676_ GPGLR 681_ PGEDP 686_ KGPFG 691_ RSFST 696_ SRLTD 701_ LLLKA 706_ AFGTQ 711_ APDPG 716_ STESL 721_ QEKPM 726_ EIAPS 731_ AGFGG 736_ SLHPG 741_ ARAGG 746_ TSSPS 751_ PVVFT 756_ VGSPP 761_ SGSTP 766_ PQGPR 771_ TRMFS 776_ AGPTG 781_ SASSS 786_ ARHLV 791_ PGPCS 796_ EAPAP 801_ ELPAP 806_ GHGCS 811_ FADPI 816_ TANLE 821_ GAVTF 826_ EAPDL 831_ PEETL 836_ MEQEH 841_ TEILR 846_ GLRFT 851_ LLFVQ 856_ HVLEI 861_ AALKG 866_ SASEA 871_ AGGPE 876_ YQLQE 881_ SVVAD 886_ QISLL 891_ SREWG 896_ FAEQL 901_ VLYLK 906_ VAELL 911_ SSGLQ 916_ SAIDQ 921_ IRAGK 926_ LCLSS 931_ TVKQV 936_ VRRLN 941_ ELYKA 946_ SVVSC 951_ QGLSL 956_ RLQRF 961_ FLDKQ 966_ RLLDR 971_ IHSIT 976_ AERLI 981_ FSHAV 986_ QMVQS 991_ AALDE 996_ MFQHR 1001_ EGCVP 1006_ RYHKA 1011_ LLLLE 1016_ GLQHM 1021_ LSDQA 1026_ DIENV 1031_ TKCKL 1036_ CIERR 1041_LSALL
1: Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708)