Tubby-related protein 3 (Tubby-like protein 3)
1_MEASR 6_ CRLSP 11_ SGDSV 16_ FHEEM 21_ MKMRQ 26_ AKLDY 31_ QRLLL 36_ EKRQR 41_ KKRLE 46_ PFMVQ 51_ PNPEA 56_ RLRRA 61_ KPRAS 66_ DEQTP 71_ LVNCH 76_ TPHSN 81_ VILHG 86_ IDGPA 91_ AVLKP 96_ DEVHA 101_ PSVSS 106_ SVVEE 111_ DAENT 116_ VDTAS 121_ KPGLQ 126_ ERLQK 131_ HDISE 136_ SVNFD 141_ EETDG 146_ ISQSA 151_ CLERP 156_ NSASS 161_ QNSTD 166_ TGTSG 171_ SATAA 176_ QPADN 181_ LLGDI 186_ DDLED 191_ FVYSP 196_ APQGV 201_ TVRCR 206_ IIRDK 211_ RGMDR 216_ GLFPT 221_ YYMYL 226_ EKEEN 231_ QKIFL 236_ LAARK 241_ RKKSK 246_ TANYL 251_ ISIDP 256_ VDLSR 261_ EGESY 266_ VGKLR 271_ SNLMG 276_ TKFTV 281_ YDRGI 286_ CPMKG 291_ RGLVG 296_ AAHTR 301_ QELAA 306_ ISYET 311_ NVLGF 316_ KGPRK 321_ MSVII 326_ PGMTL 331_ NHKQI 336_ PYQPQ 341_ NNHDS 346_ LLSRW 351_ QNRTM 356_ ENLVE 361_ LHNKA 366_ PVWNS 371_ DTQSY 376_ VLNFR 381_ GRVTQ 386_ ASVKN 391_ FQIVH 396_ KNDPD 401_ YIVMQ 406_ FGRVA 411_ DDVFT 416_ LDYNY 421_ PLCAV 426_ QAFGI 431_ GLSSF 436_DSKLA
1: Negative regulator of the Shh signaling transduction pathway: recruited to primary cilia via association with the IFT complex A (IFT-A) and is required for recruitment of G protein-coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. During adipogenesis, regulates ciliary trafficking of FFAR4 in preadipocytes