DNA polymerase theta (EC 2.7.7.7) (DNA polymerase eta)
1_MNLLR 6_ RSGKR 11_ RRSES 16_ GSDSF 21_ SGSGG 26_ DSSAS 31_ PQFLS 36_ GSVLS 41_ PPPGL 46_ GRCLK 51_ AAAAG 56_ ECKPT 61_ VPDYE 66_ RDKLL 71_ LANWG 76_ LPKAV 81_ LEKYH 86_ SFGVK 91_ KMFEW 96_ QAECL 101_ LLGQV 106_ LEGKN 111_ LVYSA 116_ PTSAG 121_ KTLVA 126_ ELLIL 131_ KRVLE 136_ MRKKA 141_ LFILP 146_ FVSVA 151_ KEKKY 156_ YLQSL 161_ FQEVG 166_ IKVDG 171_ YMGST 176_ SPSRH 181_ FSSLD 186_ IAVCT 191_ IERAN 196_ GLINR 201_ LIEEN 206_ KMDLL 211_ GMVVV 216_ DELHM 221_ LGDSH 226_ RGYLL 231_ ELLLT 236_ KICYI 241_ TRKSA 246_ SCQAD 251_ LASSL 256_ SNAVQ 261_ IVGMS 266_ ATLPN 271_ LELVA 276_ SWLNA 281_ ELYHT 286_ DFRPV 291_ PLLES 296_ VKVGN 301_ SIYDS 306_ SMKLV 311_ REFEP 316_ MLQVK 321_ GDEDH 326_ VVSLC 331_ YETIC 336_ DNHSV 341_ LLFCP 346_ SKKWC 351_ EKLAD 356_ IIARE 361_ FYNLH 366_ HQAEG 371_ LVKPS 376_ ECPPV 381_ ILEQK 386_ ELLEV 391_ MDQLR 396_ RLPSG 401_ LDSVL 406_ QKTVP 411_ WGVAF 416_ HHAGL 421_ TFEER 426_ DIIEG 431_ AFRQG 436_ LIRVL 441_ AATST 446_ LSSGV 451_ NLPAR 456_ RVIIR 461_ TPIFG 466_ GRPLD 471_ ILTYK 476_ QMVGR 481_ AGRKG 486_ VDTVG 491_ ESILI 496_ CKNSE 501_ KSKGI 506_ ALLQG 511_ SLKPV 516_ RSCLQ 521_ RREGE 526_ EVTGS 531_ MIRAI 536_ LEIIV 541_ GGVAS 546_ TSQDM 551_ HTYAA 556_ CTFLA 561_ ASMKE 566_ GKQGI 571_ QRNQE 576_ SVQLG 581_ AIEAC 586_ VMWLL 591_ ENEFI 596_ QSTEA 601_ SDGTE 606_ GKVYH 611_ PTHLG 616_ SATLS 621_ SSLSP 626_ ADTLD 631_ IFADL 636_ QRAMK 641_ GFVLE 646_ NDLHI 651_ LYLVT 656_ PMFED 661_ WTTID 666_ WYRFF 671_ CLWEK 676_ LPTSM 681_ KRVAE 686_ LVGVE 691_ EGFLA 696_ RCVKG 701_ KVVAR 706_ TERQH 711_ RQMAI 716_ HKRFF 721_ TSLVL 726_ LDLIS 731_ EVPLR 736_ EINQK 741_ YGCNR 746_ GQIQS 751_ LQQSA 756_ AVYAG 761_ MITVF 766_ SNRLG 771_ WHNME 776_ LLLSQ 781_ FQKRL 786_ TFGIQ 791_ RELCD 796_ LVRVS 801_ LLNAQ 806_ RARVL 811_ YASGF 816_ HTVAD 821_ LARAN 826_ IVEVE 831_ VILKN 836_ AVPFK 841_ SARKA 846_ VDEEE 851_ EAVEE 856_ RRNMR 861_ TIWVT 866_ GRKGL 871_ TEREA 876_ AALIV 881_ EEARM 886_ ILQQD 891_ LVEMG 896_ VQWNP 901_ CALLH 906_ SSTCS 911_ LTHSE 916_ SEVKE 921_ HTFIS 926_ QTKSS 931_ YKKLT 936_ SKNKS 941_ NTIFS 946_ DSYIK 951_ HSPNI 956_ VQDLN 961_ KSREH 966_ TSSFN 971_ CNFQN 976_ GNQEH 981_ QTCSI 986_ FRARK 991_ RASLD 996_ INKEK 1001_ PGASQ 1006_ NEGKT 1011_ SDKKV 1016_ VQTFS 1021_ QKTKK 1026_ APLNF 1031_ NSEKM 1036_ SRSFR 1041_ SWKRR 1046_ KHLKR 1051_ SRDSS 1056_ PLKDS 1061_ GACRI 1066_ HLQGQ 1071_ TLSNP 1076_ SLCED 1081_ PFTLD 1086_ EKKTE 1091_ FRNSG 1096_ PFAKN 1101_ VSLSG 1106_ KEKDN 1111_ KTSFP 1116_ LQIKQ 1121_ NCSWN 1126_ ITLTN 1131_ DNFVE 1136_ HIVTG 1141_ SQSKN 1146_ VTCQA 1151_ TSVVS 1156_ EKGRG 1161_ VAVEA 1166_ EKINE 1171_ VLIQN 1176_ GSKNQ 1181_ NVYMK 1186_ HHDIH 1191_ PINQY 1196_ LRKQS 1201_ HEQTS 1206_ TITKQ 1211_ KNIIE 1216_ RQMPC 1221_ EAVSS 1226_ YINRD 1231_ SNVTI 1236_ NCERI 1241_ KLNTE 1246_ ENKPS 1251_ HFQAL 1256_ GDDIS 1261_ RTVIP 1266_ SEVLP 1271_ SAGAF 1276_ SKSEG 1281_ QHENF 1286_ LNISR 1291_ LQEKT 1296_ GTYTT 1301_ NKTKN 1306_ NHVSD 1311_ LGLVL 1316_ CDFED 1321_ SFYLD 1326_ TQSEK 1331_ IIQQM 1336_ ATENA 1341_ KLGAK 1346_ DTNLA 1351_ AGIMQ 1356_ KSLVQ 1361_ QNSMN 1366_ SFQKE 1371_ CHIPF 1376_ PAEQH 1381_ PLGAT 1386_ KIDHL 1391_ DLKTV 1396_ GTMKQ 1401_ SSDSH 1406_ GVDIL 1411_ TPESP 1416_ IFHSP 1421_ ILLEE 1426_ NGLFL 1431_ KKNEV 1436_ SVTDS 1441_ QLNSF 1446_ LQGYQ 1451_ TQETV 1456_ KPVIL 1461_ LIPQK 1466_ RTPTG 1471_ VEGEC 1476_ LPVPE 1481_ TSLNM 1486_ SDSLL 1491_ FDSFS 1496_ DDYLV 1501_ KEQLP 1506_ DMQMK 1511_ EPLPS 1516_ EVTSN 1521_ HFSDS 1526_ LCLQE 1531_ DLIKK 1536_ SNVNE 1541_ NQDTH 1546_ QQLTC 1551_ SNDES 1556_ IIFSE 1561_ MDSVQ 1566_ MVEAL 1571_ DNVDI 1576_ FPVQE 1581_ KNHTV 1586_ VSPRA 1591_ LELSD 1596_ PVLDE 1601_ HHQGD 1606_ QDGGD 1611_ QDERA 1616_ EKSKL 1621_ TGTRQ 1626_ NHSFI 1631_ WSGAS 1636_ FDLSP 1641_ GLQRI 1646_ LDKVS 1651_ SPLEN 1656_ EKLKS 1661_ MTINF 1666_ SSLNR 1671_ KNTEL 1676_ NEEQE 1681_ VISNL 1686_ ETKQV 1691_ QGISF 1696_ SSNNE 1701_ VKSKI 1706_ EMLEN 1711_ NANHD 1716_ ETSSL 1721_ LPRKE 1726_ SNIVD 1731_ DNGLI 1736_ PPTPI 1741_ PTSAS 1746_ KLTFP 1751_ GILET 1756_ PVNPW 1761_ KTNNV 1766_ LQPGE 1771_ SYLFG 1776_ SPSDI 1781_ KNHDL 1786_ SPGSR 1791_ NGFKD 1796_ NSPIS 1801_ DTSFS 1806_ LQLSQ 1811_ DGLQL 1816_ TPASS 1821_ SSESL 1826_ SIIDV 1831_ ASDQN 1836_ LFQTF 1841_ IKEWR 1846_ CKKRF 1851_ SISLA 1856_ CEKIR 1861_ SLTSS 1866_ KTATI 1871_ GSRFK 1876_ QASSP 1881_ QEIPI 1886_ RDDGF 1891_ PIKGC 1896_ DDTLV 1901_ VGLAV 1906_ CWGGR 1911_ DAYYF 1916_ SLQKE 1921_ QKHSE 1926_ ISASL 1931_ VPPSL 1936_ DPSLT 1941_ LKDRM 1946_ WYLQS 1951_ CLRKE 1956_ SDKEC 1961_ SVVIY 1966_ DFIQS 1971_ YKILL 1976_ LSCGI 1981_ SLEQS 1986_ YEDPK 1991_ VACWL 1996_ LDPDS 2001_ QEPTL 2006_ HSIVT 2011_ SFLPH 2016_ ELPLL 2021_ EGMET 2026_ SQGIQ 2031_ SLGLN 2036_ AGSEH 2041_ SGRYR 2046_ ASVES 2051_ ILIFN 2056_ SMNQL 2061_ NSLLQ 2066_ KENLQ 2071_ DVFRK 2076_ VEMPS 2081_ QYCLA 2086_ LLELN 2091_ GIGFS 2096_ TAECE 2101_ SQKHI 2106_ MQAKL 2111_ DAIET 2116_ QAYQL 2121_ AGHSF 2126_ SFTSS 2131_ DDIAE 2136_ VLFLE 2141_ LKLPP 2146_ NREMK 2151_ NQGSK 2156_ KTLGS 2161_ TRRGI 2166_ DNGRK 2171_ LRLGR 2176_ QFSTS 2181_ KDVLN 2186_ KLKAL 2191_ HPLPG 2196_ LILEW 2201_ RRITN 2206_ AITKV 2211_ VFPLQ 2216_ REKCL 2221_ NPFLG 2226_ MERIY 2231_ PVSQS 2236_ HTATG 2241_ RITFT 2246_ EPNIQ 2251_ NVPRD 2256_ FEIKM 2261_ PTLVG 2266_ ESPPS 2271_ QAVGK 2276_ GLLPM 2281_ GRGKY 2286_ KKGFS 2291_ VNPRC 2296_ QAQME 2301_ ERAAD 2306_ RGMPF 2311_ SISMR 2316_ HAFVP 2321_ FPGGS 2326_ ILAAD 2331_ YSQLE 2336_ LRILA 2341_ HLSHD 2346_ RRLIQ 2351_ VLNTG 2356_ ADVFR 2361_ SIAAE 2366_ WKMIE 2371_ PESVG 2376_ DDLRQ 2381_ QAKQI 2386_ CYGII 2391_ YGMGA 2396_ KSLGE 2401_ QMGIK 2406_ ENDAA 2411_ CYIDS 2416_ FKSRY 2421_ TGINQ 2426_ FMTET 2431_ VKNCK 2436_ RDGFV 2441_ QTILG 2446_ RRRYL 2451_ PGIKD 2456_ NNPYR 2461_ KAHAE 2466_ RQAIN 2471_ TIVQG 2476_ SAADI 2481_ VKIAT 2486_ VNIQK 2491_ QLETF 2496_ HSTFK 2501_ SHGHR 2506_ EGMLQ 2511_ SDQTG 2516_ LSRKR 2521_ KLQGM 2526_ FCPIR 2531_ GGFFI 2536_ LQLHD 2541_ ELLYE 2546_ VAEED 2551_ VVQVA 2556_ QIVKN 2561_ EMESA 2566_ VKLSV 2571_ KLKVK 2576_ VKIGA 2581_SWGEL
1: Low-fidelity DNA polymerase with a helicase activity that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery required to repair double-strand breaks in DNA during mitosis (PubMed:14576298, PubMed:18503084, PubMed:24648516, PubMed:25642963, PubMed:25643323, PubMed:25775267, PubMed:26636256, PubMed:27311885, PubMed:27591252, PubMed:30655289, PubMed:31562312, PubMed:32873648, PubMed:34140467, PubMed:34179826, PubMed:36455556, PubMed:37440612, PubMed:37674080). MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation (PubMed:25642963, PubMed:25643323, PubMed:25775267, PubMed:27311885, PubMed:27591252, PubMed:31562312, PubMed:32873648). MMEJ is required during mitosis to repair persistent double-strand breaks that originate in S-phase (PubMed:37440612, PubMed:37674080). Although error-prone, MMEJ protects against chromosomal instability and tumorigenesis (By similarity). The polymerase acts by binding directly the 2 ends of resected double-strand breaks, allowing microhomologous sequences in the overhangs to form base pairs (PubMed:25643323, PubMed:25775267, PubMed:27311885, PubMed:27591252). It then extends each strand from the base-paired region using the opposing overhang as a template (PubMed:25643323, PubMed:25775267, PubMed:27311885, PubMed:27591252). Requires partially resected DNA containing 2 to 6 base pairs of microhomology to perform MMEJ (PubMed:25643323, PubMed:25775267, PubMed:27311885, PubMed:27591252). The polymerase lacks proofreading activity and is highly promiscuous: unlike most polymerases, promotes extension of ssDNA and partial ssDNA (pssDNA) substrates (PubMed:18503084, PubMed:21050863, PubMed:22135286). When the ends of a break do not contain terminal microhomology must identify embedded complementary sequences through a scanning step (PubMed:32234782). Also acts as a DNA helicase, promoting dissociation of the replication protein A complex (RPA/RP-A), composed of RPA1, RPA2 and RPA3, from resected double-strand breaks to allow their annealing and subsequent joining by MMEJ (PubMed:36455556). Removal of RPA/RP-A complex proteins prevents RAD51 accumulation at resected ends, thereby inhibiting homology-recombination repair (HR) pathway (PubMed:25642963, PubMed:28695890). Also shows RNA-directed DNA polymerase activity to mediate DNA repair in vitro; however this activity needs additional evidence in vivo (PubMed:34117057). May also have lyase activity (PubMed:19188258). Involved in somatic hypermutation of immunoglobulin genes, a process that requires the activity of DNA polymerases to ultimately introduce mutations at both A/T and C/G base pairs (By similarity). POLQ-mediated end joining activity is involved in random integration of exogenous DNA hampers (PubMed:28695890)